Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PCJ

X-ray structure of CypA-C52AK125C/CsA/aromatic foldamer complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001666	biological_process	response to hypoxia
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006457	biological_process	protein folding
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006915	biological_process	apoptotic process
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0019076	biological_process	viral release from host cell
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031982	cellular_component	vesicle
A	0032148	biological_process	activation of protein kinase B activity
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032991	cellular_component	protein-containing complex
A	0034389	biological_process	lipid droplet organization
A	0034599	biological_process	cellular response to oxidative stress
A	0034774	cellular_component	secretory granule lumen
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0042118	biological_process	endothelial cell activation
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045069	biological_process	regulation of viral genome replication
A	0045070	biological_process	positive regulation of viral genome replication
A	0046790	molecular_function	virion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060352	biological_process	cell adhesion molecule production
A	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1903901	biological_process	negative regulation of viral life cycle
A	1904399	molecular_function	heparan sulfate binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001233	biological_process	regulation of apoptotic signaling pathway
D	0000413	biological_process	protein peptidyl-prolyl isomerization
D	0001666	biological_process	response to hypoxia
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0003723	molecular_function	RNA binding
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006457	biological_process	protein folding
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006915	biological_process	apoptotic process
D	0016018	molecular_function	cyclosporin A binding
D	0016020	cellular_component	membrane
D	0016853	molecular_function	isomerase activity
D	0019076	biological_process	viral release from host cell
D	0030168	biological_process	platelet activation
D	0030182	biological_process	neuron differentiation
D	0030593	biological_process	neutrophil chemotaxis
D	0030595	biological_process	leukocyte chemotaxis
D	0031982	cellular_component	vesicle
D	0032148	biological_process	activation of protein kinase B activity
D	0032873	biological_process	negative regulation of stress-activated MAPK cascade
D	0032991	cellular_component	protein-containing complex
D	0034389	biological_process	lipid droplet organization
D	0034599	biological_process	cellular response to oxidative stress
D	0034774	cellular_component	secretory granule lumen
D	0035307	biological_process	positive regulation of protein dephosphorylation
D	0042118	biological_process	endothelial cell activation
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043410	biological_process	positive regulation of MAPK cascade
D	0045069	biological_process	regulation of viral genome replication
D	0045070	biological_process	positive regulation of viral genome replication
D	0046790	molecular_function	virion binding
D	0050714	biological_process	positive regulation of protein secretion
D	0051082	molecular_function	unfolded protein binding
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0060352	biological_process	cell adhesion molecule production
D	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
D	0070062	cellular_component	extracellular exosome
D	0070527	biological_process	platelet aggregation
D	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D	1903901	biological_process	negative regulation of viral life cycle
D	1904399	molecular_function	heparan sulfate binding
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2001233	biological_process	regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG

Chain	Residue	Details
A	TYR50-GLY67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	MET3
D	MET3

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000269\|PubMed:25489052, ECO:0000269\|Ref.12, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	VAL4
D	VAL4

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS30
A	LYS84
D	LYS30
D	LYS84

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS46
A	LYS78
A	LYS133
D	LYS46
D	LYS78
D	LYS133

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER79
D	SER79

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	THR95
D	THR95

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:20364129, ECO:0000269\|PubMed:25678563, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	CYS127
D	CYS127

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P17742

Chain	Residue	Details
A	LYS135
D	LYS135

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN110
D	ASN110

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	LYS30
D	LYS30

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS84
D	LYS84

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
A	ARG57	electrostatic stabiliser, hydrogen bond donor, steric role
A	PHE62	polar/non-polar interaction, steric role
A	GLN65	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ASN104	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	PHE115	polar/non-polar interaction, steric role
A	LEU124	polar/non-polar interaction, steric role
A	HIS128	polar/non-polar interaction, steric role

site_id	MCSA2
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
D	ARG57	electrostatic stabiliser, hydrogen bond donor, steric role
D	PHE62	polar/non-polar interaction, steric role
D	GLN65	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
D	ASN104	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
D	PHE115	polar/non-polar interaction, steric role
D	LEU124	polar/non-polar interaction, steric role
D	HIS128	polar/non-polar interaction, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)