7PB0

Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGsPP and IsPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002094	molecular_function	polyprenyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006486	biological_process	protein glycosylation
A	0006489	biological_process	dolichyl diphosphate biosynthetic process
A	0006629	biological_process	lipid metabolic process
A	0016020	cellular_component	membrane
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0045547	molecular_function	dehydrodolichyl diphosphate synthase activity
A	0046872	molecular_function	metal ion binding
A	1904423	cellular_component	dehydrodolichyl diphosphate synthase complex
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019408	biological_process	dolichol biosynthetic process
B	1904423	cellular_component	dehydrodolichyl diphosphate synthase complex

Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DILIRTSGevRlSdFLLW

Chain	Residue	Details
A	ASP201-TRP218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	TRANSMEM: Helical; Name=3 => ECO:0000303|PubMed:21572394

Chain	Residue	Details
B	ILE117-TYR135
A	ARG38
A	ARG85
A	ARG205
A	ARG211
A	SER213

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:32817466

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21572394

Chain	Residue	Details
B	ASN144
B	ALA280

---