7P70
The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35-E6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001533 | cellular_component | cornified envelope |
| A | 0001765 | biological_process | membrane raft assembly |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0001921 | biological_process | positive regulation of receptor recycling |
| A | 0002020 | molecular_function | protease binding |
| A | 0002091 | biological_process | negative regulation of receptor internalization |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004859 | molecular_function | phospholipase inhibitor activity |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0006900 | biological_process | vesicle budding from membrane |
| A | 0007155 | biological_process | cell adhesion |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0009986 | cellular_component | cell surface |
| A | 0010756 | biological_process | positive regulation of plasminogen activation |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016363 | cellular_component | nuclear matrix |
| A | 0019834 | molecular_function | phospholipase A2 inhibitor activity |
| A | 0030496 | cellular_component | midbody |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031340 | biological_process | positive regulation of vesicle fusion |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0031982 | cellular_component | vesicle |
| A | 0032804 | biological_process | negative regulation of low-density lipoprotein particle receptor catabolic process |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0035749 | cellular_component | myelin sheath adaxonal region |
| A | 0036035 | biological_process | osteoclast development |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042470 | cellular_component | melanosome |
| A | 0042789 | biological_process | mRNA transcription by RNA polymerase II |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043220 | cellular_component | Schmidt-Lanterman incisure |
| A | 0044090 | biological_process | positive regulation of vacuole organization |
| A | 0044548 | molecular_function | S100 protein binding |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045921 | biological_process | positive regulation of exocytosis |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0050767 | biological_process | regulation of neurogenesis |
| A | 0051051 | biological_process | negative regulation of transport |
| A | 0051240 | biological_process | positive regulation of multicellular organismal process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098609 | biological_process | cell-cell adhesion |
| A | 0098641 | molecular_function | cadherin binding involved in cell-cell adhesion |
| A | 1905581 | biological_process | positive regulation of low-density lipoprotein particle clearance |
| A | 1905602 | biological_process | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| A | 1905686 | biological_process | positive regulation of plasma membrane repair |
| A | 1990665 | cellular_component | AnxA2-p11 complex |
| A | 1990667 | cellular_component | PCSK9-AnxA2 complex |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GVdevtivniLtnRsneQrqDiafaYqrrtkkeLasaLksalsGhletvIlgL |
| Chain | Residue | Details |
| A | GLY226-LEU278 | |
| A | GLY298-LEU350 | |
| A | GLY383-LEU435 | |
| A | GLY458-LEU510 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Motif: {"description":"PDZ-binding domain","evidences":[{"source":"HAMAP-Rule","id":"MF_04006","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"15302870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28669632","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"28669632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2946940","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P07356","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P07356","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P07356","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 83 |
| Details | Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
