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7P6X

Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000492biological_processbox C/D snoRNP assembly
A0000723biological_processtelomere maintenance
A0000786cellular_componentnucleosome
A0000812cellular_componentSwr1 complex
A0001094molecular_functionTFIID-class transcription factor complex binding
A0003678molecular_functionDNA helicase activity
A0003689molecular_functionDNA clamp loader activity
A0003713molecular_functiontranscription coactivator activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006310biological_processDNA recombination
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0007283biological_processspermatogenesis
A0008094molecular_functionATP-dependent activity, acting on DNA
A0009378molecular_functionfour-way junction helicase activity
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017025molecular_functionTBP-class protein binding
A0031011cellular_componentIno80 complex
A0032508biological_processDNA duplex unwinding
A0033044biological_processregulation of chromosome organization
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0036121molecular_functiondouble-stranded DNA helicase activity
A0042981biological_processregulation of apoptotic process
A0043531molecular_functionADP binding
A0045296molecular_functioncadherin binding
A0045739biological_processpositive regulation of DNA repair
A0045893biological_processpositive regulation of DNA-templated transcription
A0045995biological_processregulation of embryonic development
A0050821biological_processprotein stabilization
A0051117molecular_functionATPase binding
A0051276biological_processchromosome organization
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060382biological_processregulation of DNA strand elongation
A0061749molecular_functionforked DNA-dependent helicase activity
A0061775molecular_functioncohesin loader activity
A0070062cellular_componentextracellular exosome
A0071339cellular_componentMLL1 complex
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0090671biological_processtelomerase RNA localization to Cajal body
A0097255cellular_componentR2TP complex
A0101031cellular_componentprotein folding chaperone complex
A0120293cellular_componentdynein axonemal particle
A0140584molecular_functionchromatin extrusion motor activity
A0140588biological_processchromatin looping
A0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
A0140849molecular_functionATP-dependent H2AZ histone chaperone activity
A1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
A1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
A1990904cellular_componentribonucleoprotein complex
A2000779biological_processregulation of double-strand break repair
B0000492biological_processbox C/D snoRNP assembly
B0000723biological_processtelomere maintenance
B0000786cellular_componentnucleosome
B0000812cellular_componentSwr1 complex
B0001094molecular_functionTFIID-class transcription factor complex binding
B0003678molecular_functionDNA helicase activity
B0003689molecular_functionDNA clamp loader activity
B0003713molecular_functiontranscription coactivator activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006310biological_processDNA recombination
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0007283biological_processspermatogenesis
B0008094molecular_functionATP-dependent activity, acting on DNA
B0009378molecular_functionfour-way junction helicase activity
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017025molecular_functionTBP-class protein binding
B0031011cellular_componentIno80 complex
B0032508biological_processDNA duplex unwinding
B0033044biological_processregulation of chromosome organization
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0036121molecular_functiondouble-stranded DNA helicase activity
B0042981biological_processregulation of apoptotic process
B0043531molecular_functionADP binding
B0045296molecular_functioncadherin binding
B0045739biological_processpositive regulation of DNA repair
B0045893biological_processpositive regulation of DNA-templated transcription
B0045995biological_processregulation of embryonic development
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0051276biological_processchromosome organization
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060382biological_processregulation of DNA strand elongation
B0061749molecular_functionforked DNA-dependent helicase activity
B0061775molecular_functioncohesin loader activity
B0070062cellular_componentextracellular exosome
B0071339cellular_componentMLL1 complex
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0090671biological_processtelomerase RNA localization to Cajal body
B0097255cellular_componentR2TP complex
B0101031cellular_componentprotein folding chaperone complex
B0120293cellular_componentdynein axonemal particle
B0140584molecular_functionchromatin extrusion motor activity
B0140588biological_processchromatin looping
B0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
B0140849molecular_functionATP-dependent H2AZ histone chaperone activity
B1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
B1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
B1990904cellular_componentribonucleoprotein complex
B2000779biological_processregulation of double-strand break repair
C0000492biological_processbox C/D snoRNP assembly
C0000723biological_processtelomere maintenance
C0000786cellular_componentnucleosome
C0000812cellular_componentSwr1 complex
C0001094molecular_functionTFIID-class transcription factor complex binding
C0003678molecular_functionDNA helicase activity
C0003689molecular_functionDNA clamp loader activity
C0003713molecular_functiontranscription coactivator activity
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006310biological_processDNA recombination
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0007283biological_processspermatogenesis
C0008094molecular_functionATP-dependent activity, acting on DNA
C0009378molecular_functionfour-way junction helicase activity
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017025molecular_functionTBP-class protein binding
C0031011cellular_componentIno80 complex
C0032508biological_processDNA duplex unwinding
C0033044biological_processregulation of chromosome organization
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0036121molecular_functiondouble-stranded DNA helicase activity
C0042981biological_processregulation of apoptotic process
C0043531molecular_functionADP binding
C0045296molecular_functioncadherin binding
C0045739biological_processpositive regulation of DNA repair
C0045893biological_processpositive regulation of DNA-templated transcription
C0045995biological_processregulation of embryonic development
C0050821biological_processprotein stabilization
C0051117molecular_functionATPase binding
C0051276biological_processchromosome organization
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0060382biological_processregulation of DNA strand elongation
C0061749molecular_functionforked DNA-dependent helicase activity
C0061775molecular_functioncohesin loader activity
C0070062cellular_componentextracellular exosome
C0071339cellular_componentMLL1 complex
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0090671biological_processtelomerase RNA localization to Cajal body
C0097255cellular_componentR2TP complex
C0101031cellular_componentprotein folding chaperone complex
C0120293cellular_componentdynein axonemal particle
C0140584molecular_functionchromatin extrusion motor activity
C0140588biological_processchromatin looping
C0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
C0140849molecular_functionATP-dependent H2AZ histone chaperone activity
C1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
C1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
C1990904cellular_componentribonucleoprotein complex
C2000779biological_processregulation of double-strand break repair
D0000492biological_processbox C/D snoRNP assembly
D0000723biological_processtelomere maintenance
D0000786cellular_componentnucleosome
D0000791cellular_componenteuchromatin
D0000812cellular_componentSwr1 complex
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
D0001094molecular_functionTFIID-class transcription factor complex binding
D0003678molecular_functionDNA helicase activity
D0003689molecular_functionDNA clamp loader activity
D0003714molecular_functiontranscription corepressor activity
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006275biological_processregulation of DNA replication
D0006281biological_processDNA repair
D0006282biological_processregulation of DNA repair
D0006310biological_processDNA recombination
D0006325biological_processchromatin organization
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006457biological_processprotein folding
D0008013molecular_functionbeta-catenin binding
D0008094molecular_functionATP-dependent activity, acting on DNA
D0009378molecular_functionfour-way junction helicase activity
D0016020cellular_componentmembrane
D0016363cellular_componentnuclear matrix
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017025molecular_functionTBP-class protein binding
D0031011cellular_componentIno80 complex
D0031490molecular_functionchromatin DNA binding
D0032508biological_processDNA duplex unwinding
D0033044biological_processregulation of chromosome organization
D0034644biological_processcellular response to UV
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0036121molecular_functiondouble-stranded DNA helicase activity
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042981biological_processregulation of apoptotic process
D0043531molecular_functionADP binding
D0045739biological_processpositive regulation of DNA repair
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0045995biological_processregulation of embryonic development
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0051117molecular_functionATPase binding
D0051276biological_processchromosome organization
D0051726biological_processregulation of cell cycle
D0060382biological_processregulation of DNA strand elongation
D0061749molecular_functionforked DNA-dependent helicase activity
D0061775molecular_functioncohesin loader activity
D0070062cellular_componentextracellular exosome
D0071169biological_processestablishment of protein localization to chromatin
D0071339cellular_componentMLL1 complex
D0071392biological_processcellular response to estradiol stimulus
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090671biological_processtelomerase RNA localization to Cajal body
D0097255cellular_componentR2TP complex
D0101031cellular_componentprotein folding chaperone complex
D0120293cellular_componentdynein axonemal particle
D0140584molecular_functionchromatin extrusion motor activity
D0140585molecular_functionpromoter-enhancer loop anchoring activity
D0140588biological_processchromatin looping
D0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
D0140849molecular_functionATP-dependent H2AZ histone chaperone activity
D1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
D1905168biological_processpositive regulation of double-strand break repair via homologous recombination
D1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
D1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
D1990904cellular_componentribonucleoprotein complex
D2000779biological_processregulation of double-strand break repair
E0000492biological_processbox C/D snoRNP assembly
E0000723biological_processtelomere maintenance
E0000786cellular_componentnucleosome
E0000791cellular_componenteuchromatin
E0000812cellular_componentSwr1 complex
E0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
E0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
E0001094molecular_functionTFIID-class transcription factor complex binding
E0003678molecular_functionDNA helicase activity
E0003689molecular_functionDNA clamp loader activity
E0003714molecular_functiontranscription corepressor activity
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0006275biological_processregulation of DNA replication
E0006281biological_processDNA repair
E0006282biological_processregulation of DNA repair
E0006310biological_processDNA recombination
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0006355biological_processregulation of DNA-templated transcription
E0006357biological_processregulation of transcription by RNA polymerase II
E0006457biological_processprotein folding
E0008013molecular_functionbeta-catenin binding
E0008094molecular_functionATP-dependent activity, acting on DNA
E0009378molecular_functionfour-way junction helicase activity
E0016020cellular_componentmembrane
E0016363cellular_componentnuclear matrix
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0017025molecular_functionTBP-class protein binding
E0031011cellular_componentIno80 complex
E0031490molecular_functionchromatin DNA binding
E0032508biological_processDNA duplex unwinding
E0033044biological_processregulation of chromosome organization
E0034644biological_processcellular response to UV
E0035267cellular_componentNuA4 histone acetyltransferase complex
E0036121molecular_functiondouble-stranded DNA helicase activity
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0042981biological_processregulation of apoptotic process
E0043531molecular_functionADP binding
E0045739biological_processpositive regulation of DNA repair
E0045892biological_processnegative regulation of DNA-templated transcription
E0045893biological_processpositive regulation of DNA-templated transcription
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0045995biological_processregulation of embryonic development
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051117molecular_functionATPase binding
E0051276biological_processchromosome organization
E0051726biological_processregulation of cell cycle
E0060382biological_processregulation of DNA strand elongation
E0061749molecular_functionforked DNA-dependent helicase activity
E0061775molecular_functioncohesin loader activity
E0070062cellular_componentextracellular exosome
E0071169biological_processestablishment of protein localization to chromatin
E0071339cellular_componentMLL1 complex
E0071392biological_processcellular response to estradiol stimulus
E0090090biological_processnegative regulation of canonical Wnt signaling pathway
E0090671biological_processtelomerase RNA localization to Cajal body
E0097255cellular_componentR2TP complex
E0101031cellular_componentprotein folding chaperone complex
E0120293cellular_componentdynein axonemal particle
E0140584molecular_functionchromatin extrusion motor activity
E0140585molecular_functionpromoter-enhancer loop anchoring activity
E0140588biological_processchromatin looping
E0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
E0140849molecular_functionATP-dependent H2AZ histone chaperone activity
E1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
E1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
E1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
E1990904cellular_componentribonucleoprotein complex
E2000779biological_processregulation of double-strand break repair
F0000492biological_processbox C/D snoRNP assembly
F0000723biological_processtelomere maintenance
F0000786cellular_componentnucleosome
F0000791cellular_componenteuchromatin
F0000812cellular_componentSwr1 complex
F0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
F0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
F0001094molecular_functionTFIID-class transcription factor complex binding
F0003678molecular_functionDNA helicase activity
F0003689molecular_functionDNA clamp loader activity
F0003714molecular_functiontranscription corepressor activity
F0004386molecular_functionhelicase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0006275biological_processregulation of DNA replication
F0006281biological_processDNA repair
F0006282biological_processregulation of DNA repair
F0006310biological_processDNA recombination
F0006325biological_processchromatin organization
F0006338biological_processchromatin remodeling
F0006355biological_processregulation of DNA-templated transcription
F0006357biological_processregulation of transcription by RNA polymerase II
F0006457biological_processprotein folding
F0008013molecular_functionbeta-catenin binding
F0008094molecular_functionATP-dependent activity, acting on DNA
F0009378molecular_functionfour-way junction helicase activity
F0016020cellular_componentmembrane
F0016363cellular_componentnuclear matrix
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0017025molecular_functionTBP-class protein binding
F0031011cellular_componentIno80 complex
F0031490molecular_functionchromatin DNA binding
F0032508biological_processDNA duplex unwinding
F0033044biological_processregulation of chromosome organization
F0034644biological_processcellular response to UV
F0035267cellular_componentNuA4 histone acetyltransferase complex
F0036121molecular_functiondouble-stranded DNA helicase activity
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042981biological_processregulation of apoptotic process
F0043531molecular_functionADP binding
F0045739biological_processpositive regulation of DNA repair
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0045995biological_processregulation of embryonic development
F0050821biological_processprotein stabilization
F0051082molecular_functionunfolded protein binding
F0051117molecular_functionATPase binding
F0051276biological_processchromosome organization
F0051726biological_processregulation of cell cycle
F0060382biological_processregulation of DNA strand elongation
F0061749molecular_functionforked DNA-dependent helicase activity
F0061775molecular_functioncohesin loader activity
F0070062cellular_componentextracellular exosome
F0071169biological_processestablishment of protein localization to chromatin
F0071339cellular_componentMLL1 complex
F0071392biological_processcellular response to estradiol stimulus
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0090671biological_processtelomerase RNA localization to Cajal body
F0097255cellular_componentR2TP complex
F0101031cellular_componentprotein folding chaperone complex
F0120293cellular_componentdynein axonemal particle
F0140584molecular_functionchromatin extrusion motor activity
F0140585molecular_functionpromoter-enhancer loop anchoring activity
F0140588biological_processchromatin looping
F0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
F0140849molecular_functionATP-dependent H2AZ histone chaperone activity
F1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
F1905168biological_processpositive regulation of double-strand break repair via homologous recombination
F1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
F1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
F1990904cellular_componentribonucleoprotein complex
F2000779biological_processregulation of double-strand break repair
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
DGLY77
EGLY77
FGLY77

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.14, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
DALA2
EALA2
FALA2

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER437
ESER437
FSER437

site_idSWS_FT_FI4
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS9
FLYS444
FLYS456
ALYS445
DLYS444
DLYS456
ELYS9
CLYS445
ELYS444
ELYS456
FLYS9

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS225
BLYS225
CLYS225

227561

PDB entries from 2024-11-20

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