7P54

Cryo-EM structure of human TTYH2 in GDN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005225	molecular_function	volume-sensitive anion channel activity
A	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006821	biological_process	chloride transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0046872	molecular_function	metal ion binding
A	0072320	molecular_function	volume-sensitive chloride channel activity
A	1902476	biological_process	chloride transmembrane transport
B	0005225	molecular_function	volume-sensitive anion channel activity
B	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006821	biological_process	chloride transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034707	cellular_component	chloride channel complex
B	0046872	molecular_function	metal ion binding
B	0072320	molecular_function	volume-sensitive chloride channel activity
B	1902476	biological_process	chloride transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	LEU45-ALA65
B	LEU45-ALA65

---

site_id	SWS_FT_FI2
Number of Residues	300
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:18260827

Chain	Residue	Details
A	TYR66-CYS87
A	ALA235-CYS240
A	GLY410-ALA534
B	TYR66-CYS87
B	ALA235-CYS240
B	GLY410-ALA534

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	CYS88-PHE108
B	CYS88-PHE108

---

site_id	SWS_FT_FI4
Number of Residues	460
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:18260827

Chain	Residue	Details
A	TYR109-TRP213
A	ALA262-GLY388
B	TYR109-TRP213
B	ALA262-GLY388

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	LEU214-LEU234
B	LEU214-LEU234

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	LEU241-ALA261
B	LEU241-ALA261

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	LEU389-ALA409
B	LEU389-ALA409

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q3TH73

Chain	Residue	Details
A	GLU113
A	ASP116
B	GLU113
B	ASP116

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	SITE: Essential for the formation of the channel-pore => ECO:0000250|UniProtKB:Q3TH73

Chain	Residue	Details
A	ARG164
B	ARG164

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983

Chain	Residue	Details
A	THR199
B	THR199

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3TH73

Chain	Residue	Details
A	SER504
B	SER504

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18260827, ECO:0000269|PubMed:34385445

Chain	Residue	Details
A	ASN31
A	ASN283
B	ASN31
B	ASN283

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc) asparagine => ECO:0000269|PubMed:18260827, ECO:0000269|PubMed:34385445

Chain	Residue	Details
A	ASN129
A	ASN352
B	ASN129
B	ASN352

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