7P2Q
Human Signal Peptidase Complex Paralog C (SPC-C)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005787 | cellular_component | signal peptidase complex |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006465 | biological_process | signal peptide processing |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005515 | molecular_function | protein binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005787 | cellular_component | signal peptidase complex |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006465 | biological_process | signal peptide processing |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| B | 0019082 | biological_process | viral protein processing |
| B | 0045047 | biological_process | protein targeting to ER |
| C | 0005515 | molecular_function | protein binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005787 | cellular_component | signal peptidase complex |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006465 | biological_process | signal peptide processing |
| C | 0016020 | cellular_component | membrane |
| C | 0045047 | biological_process | protein targeting to ER |
| D | 0003674 | molecular_function | molecular_function |
| D | 0005515 | molecular_function | protein binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005787 | cellular_component | signal peptidase complex |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006465 | biological_process | signal peptide processing |
| D | 0006508 | biological_process | proteolysis |
| D | 0016020 | cellular_component | membrane |
| D | 0019068 | biological_process | virion assembly |
| D | 0019082 | biological_process | viral protein processing |
| D | 0045047 | biological_process | protein targeting to ER |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 22 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pmntvlsranslfa.....................................................................................................FSLSVMAA |
| Chain | Residue | Details |
| B | PRO0-ALA21 |
| site_id | PS00501 |
| Number of Residues | 8 |
| Details | SPASE_I_1 Signal peptidases I serine active site. SGSMEPAF |
| Chain | Residue | Details |
| A | SER66-PHE73 |
| site_id | PS00761 |
| Number of Residues | 14 |
| Details | SPASE_I_3 Signal peptidases I signature 3. FLTKGDNNevDdrG |
| Chain | Residue | Details |
| A | PHE123-GLY136 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 177 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q28250 |
| Chain | Residue | Details |
| C | ALA2-THR86 | |
| C | SER133-LYS226 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | ILE87-PHE107 | |
| C | PRO112-THR132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:Q28250 |
| Chain | Residue | Details |
| C | PRO108-LYS111 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:34388369, ECO:0000269|Ref.4, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| C | ALA2 | |
| A | HIS108 | |
| A | ASP134 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS169 | |
| C | LYS191 |
