7P2Q
Human Signal Peptidase Complex Paralog C (SPC-C)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005787 | cellular_component | signal peptidase complex |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006465 | biological_process | signal peptide processing |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0009003 | molecular_function | signal peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005787 | cellular_component | signal peptidase complex |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006465 | biological_process | signal peptide processing |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| B | 0019082 | biological_process | viral protein processing |
| B | 0045047 | biological_process | protein targeting to ER |
| C | 0005515 | molecular_function | protein binding |
| C | 0005787 | cellular_component | signal peptidase complex |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006465 | biological_process | signal peptide processing |
| C | 0016020 | cellular_component | membrane |
| C | 0045047 | biological_process | protein targeting to ER |
| D | 0005515 | molecular_function | protein binding |
| D | 0005787 | cellular_component | signal peptidase complex |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006465 | biological_process | signal peptide processing |
| D | 0006508 | biological_process | proteolysis |
| D | 0016020 | cellular_component | membrane |
| D | 0019068 | biological_process | virion assembly |
| D | 0019082 | biological_process | viral protein processing |
| D | 0045047 | biological_process | protein targeting to ER |
Functional Information from PROSITE/UniProt
| site_id | PS00501 |
| Number of Residues | 8 |
| Details | SPASE_I_1 Signal peptidases I serine active site. SGSMEPAF |
| Chain | Residue | Details |
| A | SER66-PHE73 |
| site_id | PS00761 |
| Number of Residues | 14 |
| Details | SPASE_I_3 Signal peptidases I signature 3. FLTKGDNNevDdrG |
| Chain | Residue | Details |
| A | PHE123-GLY136 |
| site_id | PS00430 |
| Number of Residues | 22 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pmntvlsranslfa.....................................................................................................FSLSVMAA |
| Chain | Residue | Details |
| B | PRO0-ALA21 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"34388369","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 147 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"P61008","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34388369","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"Q28250","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"P83362","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
