7P1I
Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010348 | molecular_function | lithium:proton antiporter activity |
| A | 0010351 | biological_process | lithium ion transport |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031514 | cellular_component | motile cilium |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055078 | biological_process | sodium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0097228 | cellular_component | sperm principal piece |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0010348 | molecular_function | lithium:proton antiporter activity |
| B | 0010351 | biological_process | lithium ion transport |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015385 | molecular_function | sodium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0030672 | cellular_component | synaptic vesicle membrane |
| B | 0031514 | cellular_component | motile cilium |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055037 | cellular_component | recycling endosome |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0055078 | biological_process | sodium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0097228 | cellular_component | sperm principal piece |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 414 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-ARG85 | |
| A | LEU133-PRO143 | |
| A | LEU189-LEU199 | |
| A | ALA242-LEU269 | |
| A | GLN324-ARG338 | |
| A | ALA373-ALA389 | |
| A | CYS440-ALA460 | |
| A | GLY509-VAL535 | |
| B | LEU133-PRO143 | |
| B | LEU189-LEU199 | |
| B | ALA242-LEU269 | |
| B | GLN324-ARG338 | |
| B | ALA373-ALA389 | |
| B | CYS440-ALA460 | |
| B | GLY509-VAL535 | |
| A | MET1-ARG85 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | VAL86-VAL103 | |
| A | VAL86-VAL103 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | THR104-GLY112 | |
| A | GLY227-TRP232 | |
| A | GLY290-VAL299 | |
| A | GLY357-GLY360 | |
| A | ALA411-THR416 | |
| A | THR473-TYR485 | |
| B | ILE161-LYS170 | |
| B | GLY227-TRP232 | |
| B | GLY290-VAL299 | |
| B | GLY357-GLY360 | |
| B | ALA411-THR416 | |
| B | THR473-TYR485 | |
| A | THR104-GLY112 | |
| A | ILE161-LYS170 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | ASN113-GLY132 | |
| A | ASN113-GLY132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | PRO144-VAL160 | |
| A | PRO144-VAL160 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | TRP171-GLY188 | |
| A | TRP171-GLY188 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | LYS200-MET226 | |
| A | LYS200-MET226 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | GLY233-GLY241 | |
| A | GLY233-GLY241 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | LEU270-LEU289 | |
| A | LEU270-LEU289 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | PHE300-ILE323 | |
| A | PHE300-ILE323 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | ALA339-PHE356 | |
| A | ALA339-PHE356 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | SER361-LEU372 | |
| A | SER361-LEU372 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | VAL390-THR410 | |
| A | VAL390-THR410 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | ILE417-VAL439 | |
| A | ILE417-VAL439 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | THR461-ASP472 | |
| A | THR461-ASP472 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000269|PubMed:35173351, ECO:0007744|PDB:7P1I |
| Chain | Residue | Details |
| B | GLY486-ILE508 | |
| A | GLY486-ILE508 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q86UD5 |
| Chain | Residue | Details |
| B | VAL243 | |
| B | GLY274 | |
| B | ASP277 | |
| B | ASP278 | |
| A | VAL243 | |
| A | GLY274 | |
| A | ASP277 | |
| A | ASP278 |
