7P06
Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation with ADP-orthovanadate/ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030003 | biological_process | intracellular monoatomic cation homeostasis |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046898 | biological_process | response to cycloheximide |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071944 | cellular_component | cell periphery |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. VSGGERKRVSIAEVS |
| Chain | Residue | Details |
| A | VAL309-SER323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1033 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ARG517 | |
| A | GLU580-LYS611 | |
| A | HIS651-GLU665 | |
| A | GLU794-GLN1237 | |
| A | ALA1314-GLY1324 | |
| A | PRO1380-ARG1388 | |
| A | ARG1500-LYS1511 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 246 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN518-PHE542 | |
| A | ALA1355-MET1379 | |
| A | VAL1389-VAL1407 | |
| A | ASN1477-ALA1499 | |
| A | ALA559-TYR579 | |
| A | LEU612-PHE628 | |
| A | GLY632-SER650 | |
| A | ALA666-ILE685 | |
| A | PHE775-CYS793 | |
| A | MET1238-VAL1260 | |
| A | TRP1292-ASN1313 | |
| A | ALA1325-ASN1349 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 207 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS543-SER558 | |
| A | ARG629-ASN631 | |
| A | PRO686-GLY774 | |
| A | GLN1261-PRO1291 | |
| A | GLN1350-SER1354 | |
| A | ASP1408-ARG1476 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY905 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER22 | |
| A | SER58 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | THR49 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | THR51 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER54 | |
| A | SER854 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | SER61 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER837 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | SER840 | |
| A | SER841 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER849 | |
| A | SER850 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN734 | |
| A | ASN1447 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12872131, ECO:0000269|PubMed:14557538 |
| Chain | Residue | Details |
| A | LYS825 |
