7OVC
Structure of the human UFC1 protein in complex with the UBA5 C-terminal UFC1-binding motif.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0007420 | biological_process | brain development |
| A | 0032649 | biological_process | regulation of type II interferon production |
| A | 0034976 | biological_process | response to endoplasmic reticulum stress |
| A | 0061657 | molecular_function | UFM1 conjugating enzyme activity |
| A | 0061709 | biological_process | reticulophagy |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071568 | molecular_function | UFM1 transferase activity |
| A | 0071569 | biological_process | protein ufmylation |
| A | 1990592 | biological_process | protein K69-linked ufmylation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PubMed","id":"15071506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29868776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34588452","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"35926457","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Motif: {"description":"UFC1-binding sequence (UFC)","evidences":[{"source":"PubMed","id":"34588452","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VE47","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
