7OTT

Metabolon-embedded pyruvate dehydrogenase complex E2 core at near-atomic resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
A	0005739	cellular_component	mitochondrion
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006090	biological_process	pyruvate metabolic process
A	0016746	molecular_function	acyltransferase activity
A	0045254	cellular_component	pyruvate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdaItpgEVLveIETdKAQmdFefqeeGvL

Chain	Residue	Details
A	GLY59-LEU88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:34836937, ECO:0007744|PDB:7OTT

Chain	Residue	Details
A	ARG269
A	SER283
A	ASN285
A	ARG357
A	SER374
A	ASN375

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: May form a delocalized pi-electron network with Arg-384 of 2 other E2 subunits within the complex, which greatly improves protein stability => ECO:0000269|PubMed:34836937, ECO:0007744|PDB:7OTT

Chain	Residue	Details
A	ARG384

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066

Chain	Residue	Details
A	LYS75

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