7OTT
Metabolon-embedded pyruvate dehydrogenase complex E2 core at near-atomic resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004742 | molecular_function | dihydrolipoyllysine-residue acetyltransferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
Functional Information from PROSITE/UniProt
| site_id | PS00189 |
| Number of Residues | 30 |
| Details | LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdaItpgEVLveIETdKAQmdFefqeeGvL |
| Chain | Residue | Details |
| A | GLY59-LEU88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34836937","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OTT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"May form a delocalized pi-electron network with Arg-384 of 2 other E2 subunits within the complex, which greatly improves protein stability","evidences":[{"source":"PubMed","id":"34836937","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OTT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
