7OS2
Cryo-EM structure of Brr2 in complex with Jab1/MPN and C9ORF78
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005524 | molecular_function | ATP binding |
| C | 0000398 | biological_process | mRNA splicing, via spliceosome |
| C | 0000775 | cellular_component | chromosome, centromeric region |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005681 | cellular_component | spliceosomal complex |
| C | 0005694 | cellular_component | chromosome |
| C | 0005829 | cellular_component | cytosol |
| C | 0006397 | biological_process | mRNA processing |
| C | 0007059 | biological_process | chromosome segregation |
| C | 0008380 | biological_process | RNA splicing |
| C | 0030623 | molecular_function | U5 snRNA binding |
| C | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| C | 0060629 | biological_process | regulation of homologous chromosome segregation |
| J | 0000398 | biological_process | mRNA splicing, via spliceosome |
| J | 0005681 | cellular_component | spliceosomal complex |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER15 | |
| C | SER17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| C | TYR147 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR253 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER261 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P4T2 |
| Chain | Residue | Details |
| B | THR1765 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER2002 |
