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7ON1

Cenp-A nucleosome in complex with Cenp-C

Functional Information from GO Data
ChainGOidnamespacecontents
a0000070biological_processmitotic sister chromatid segregation
a0000278biological_processmitotic cell cycle
a0000775cellular_componentchromosome, centromeric region
a0000776cellular_componentkinetochore
a0000779cellular_componentcondensed chromosome, centromeric region
a0000786cellular_componentnucleosome
a0003677molecular_functionDNA binding
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005694cellular_componentchromosome
a0005729cellular_component2-micrometer circle DNA
a0005777cellular_componentperoxisome
a0009303biological_processrRNA transcription
a0019237molecular_functioncentromeric DNA binding
a0030527molecular_functionstructural constituent of chromatin
a0030543biological_process2-micrometer plasmid partitioning
a0032991cellular_componentprotein-containing complex
a0043505cellular_componentCENP-A containing nucleosome
a0043565molecular_functionsequence-specific DNA binding
a0051382biological_processkinetochore assembly
a0061644biological_processprotein localization to CENP-A containing chromatin
b0000500cellular_componentRNA polymerase I upstream activating factor complex
b0000786cellular_componentnucleosome
b0003677molecular_functionDNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005694cellular_componentchromosome
b0006325biological_processchromatin organization
b0006334biological_processnucleosome assembly
b0006355biological_processregulation of DNA-templated transcription
b0030527molecular_functionstructural constituent of chromatin
b0031298cellular_componentreplication fork protection complex
b0032991cellular_componentprotein-containing complex
b0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
b0042802molecular_functionidentical protein binding
b0045943biological_processpositive regulation of transcription by RNA polymerase I
c0000122biological_processnegative regulation of transcription by RNA polymerase II
c0000786cellular_componentnucleosome
c0003677molecular_functionDNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005694cellular_componentchromosome
c0006281biological_processDNA repair
c0006325biological_processchromatin organization
c0030527molecular_functionstructural constituent of chromatin
c0031298cellular_componentreplication fork protection complex
c0031492molecular_functionnucleosomal DNA binding
c0031507biological_processheterochromatin formation
c0032991cellular_componentprotein-containing complex
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0000779cellular_componentcondensed chromosome, centromeric region
C0003677molecular_functionDNA binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0007052biological_processmitotic spindle organization
C0007059biological_processchromosome segregation
C0019237molecular_functioncentromeric DNA binding
C0044877molecular_functionprotein-containing complex binding
C0051301biological_processcell division
C0051315biological_processattachment of mitotic spindle microtubules to kinetochore
C0051382biological_processkinetochore assembly
C0051455biological_processspindle attachment to meiosis I kinetochore
d0000122biological_processnegative regulation of transcription by RNA polymerase II
d0000786cellular_componentnucleosome
d0003677molecular_functionDNA binding
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005694cellular_componentchromosome
d0006301biological_processpostreplication repair
d0006325biological_processchromatin organization
d0006355biological_processregulation of DNA-templated transcription
d0030527molecular_functionstructural constituent of chromatin
d0031298cellular_componentreplication fork protection complex
d0032991cellular_componentprotein-containing complex
D0000775cellular_componentchromosome, centromeric region
D0000776cellular_componentkinetochore
D0000779cellular_componentcondensed chromosome, centromeric region
D0003677molecular_functionDNA binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0007052biological_processmitotic spindle organization
D0007059biological_processchromosome segregation
D0019237molecular_functioncentromeric DNA binding
D0044877molecular_functionprotein-containing complex binding
D0051301biological_processcell division
D0051315biological_processattachment of mitotic spindle microtubules to kinetochore
D0051382biological_processkinetochore assembly
D0051455biological_processspindle attachment to meiosis I kinetochore
e0000070biological_processmitotic sister chromatid segregation
e0000278biological_processmitotic cell cycle
e0000775cellular_componentchromosome, centromeric region
e0000776cellular_componentkinetochore
e0000779cellular_componentcondensed chromosome, centromeric region
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005694cellular_componentchromosome
e0005729cellular_component2-micrometer circle DNA
e0005777cellular_componentperoxisome
e0009303biological_processrRNA transcription
e0019237molecular_functioncentromeric DNA binding
e0030527molecular_functionstructural constituent of chromatin
e0030543biological_process2-micrometer plasmid partitioning
e0032991cellular_componentprotein-containing complex
e0043505cellular_componentCENP-A containing nucleosome
e0043565molecular_functionsequence-specific DNA binding
e0051382biological_processkinetochore assembly
e0061644biological_processprotein localization to CENP-A containing chromatin
f0000500cellular_componentRNA polymerase I upstream activating factor complex
f0000786cellular_componentnucleosome
f0003677molecular_functionDNA binding
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005694cellular_componentchromosome
f0006325biological_processchromatin organization
f0006334biological_processnucleosome assembly
f0006355biological_processregulation of DNA-templated transcription
f0030527molecular_functionstructural constituent of chromatin
f0031298cellular_componentreplication fork protection complex
f0032991cellular_componentprotein-containing complex
f0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
f0042802molecular_functionidentical protein binding
f0045943biological_processpositive regulation of transcription by RNA polymerase I
g0000122biological_processnegative regulation of transcription by RNA polymerase II
g0000786cellular_componentnucleosome
g0003677molecular_functionDNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005694cellular_componentchromosome
g0006281biological_processDNA repair
g0006325biological_processchromatin organization
g0030527molecular_functionstructural constituent of chromatin
g0031298cellular_componentreplication fork protection complex
g0031492molecular_functionnucleosomal DNA binding
g0031507biological_processheterochromatin formation
g0032991cellular_componentprotein-containing complex
h0000122biological_processnegative regulation of transcription by RNA polymerase II
h0000786cellular_componentnucleosome
h0003677molecular_functionDNA binding
h0005515molecular_functionprotein binding
h0005634cellular_componentnucleus
h0005694cellular_componentchromosome
h0006301biological_processpostreplication repair
h0006325biological_processchromatin organization
h0006355biological_processregulation of DNA-templated transcription
h0030527molecular_functionstructural constituent of chromatin
h0031298cellular_componentreplication fork protection complex
h0032991cellular_componentprotein-containing complex
Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. SQEL
ChainResidueDetails
gSER129-LEU132

site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLtFPV
ChainResidueDetails
gALA23-VAL29

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
bGLY15-HIS19

site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG
ChainResidueDetails
dARG96-GLY118

site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. ILEANVKI
ChainResidueDetails
CILE400-ILE407

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFaRLVKEV
ChainResidueDetails
ePRO157-VAL165

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:16598039
ChainResidueDetails
dLYS7
dLYS8
hLYS7
hLYS8

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15652479, ECO:0000269|PubMed:15970663
ChainResidueDetails
dSER11
hSER11
bLYS13
fLYS6
fLYS9
fLYS13

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:11545749, ECO:0000269|PubMed:15186774
ChainResidueDetails
dLYS12
hLYS12

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:11545749, ECO:0000269|PubMed:15186774, ECO:0000269|PubMed:16598039, ECO:0000269|PubMed:19113941
ChainResidueDetails
dLYS17
hLYS17
fLYS32
fLYS78

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:19113941
ChainResidueDetails
dLYS18
hLYS18
cLYS14
cLYS22

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-butyryllysine; alternate => ECO:0000269|PubMed:19113941
ChainResidueDetails
dLYS22
hLYS22

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:19113941
ChainResidueDetails
dLYS23
hLYS23

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000269|PubMed:22389435
ChainResidueDetails
dLYS35
dLYS47
hLYS35
hLYS47

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6,N6-dimethyllysine => ECO:0000269|PubMed:19113941
ChainResidueDetails
dLYS38
hLYS38
cLYS127

site_idSWS_FT_FI10
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
ChainResidueDetails
dLYS7
dLYS8
hLYS7
hLYS8

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:10642555, ECO:0000269|PubMed:12535538, ECO:0000269|PubMed:12535539, ECO:0000269|PubMed:14660635, ECO:0000269|PubMed:15280549, ECO:0000269|PubMed:16432255
ChainResidueDetails
dLYS124
hLYS124

site_idSWS_FT_FI12
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate => ECO:0000305
ChainResidueDetails
dLYS17
dLYS18
hLYS17
hLYS18

224931

PDB entries from 2024-09-11

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