7OAK

Crystal structure of pseudokinase CASK in complex with compound 26

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue V6B A 401

Chain	Residue
A	ILE18
A	CYS146
A	LEU148
A	GLY161
A	GLY162
A	EDO406
A	HOH504
A	GLY19
A	ALA39
A	GLU92
A	MET94
A	ASP95
A	GLY96
A	ALA97
A	LYS105

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 402

Chain	Residue
A	ARG28
A	ILE30
B	HIS287

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 403

Chain	Residue
A	GLU13
B	LYS285

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 404

Chain	Residue
A	SER151
A	GLU153
A	PRO157
A	EDO405

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO A 405

Chain	Residue
A	GLU92
A	PHE93
A	ALA150
A	LYS159
A	EDO404
A	HOH528
A	HOH570
B	ASP108

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 406

Chain	Residue
A	ALA97
A	ASP98
A	PHE101
A	V6B401

---

site_id	AC7
Number of Residues	17
Details	binding site for residue V6B B 401

Chain	Residue
B	ILE18
B	GLY19
B	VAL26
B	ALA39
B	GLU92
B	MET94
B	ASP95
B	GLY96
B	ALA97
B	GLU102
B	LYS105
B	CYS146
B	LEU148
B	LYS152
B	GLY161
B	GLY162
B	HOH503

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO B 402

Chain	Residue
A	HIS287
B	ARG28
B	ILE30

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO B 403

Chain	Residue
B	GLU13

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO B 404

Chain	Residue
B	ALA97
B	ASP98
B	PHE101

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO B 406

Chain	Residue
A	ASP108
B	GLU92
B	PHE93
B	ALA150
B	HOH556

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO B 407

Chain	Residue
A	ASP108
B	SER151
B	GLU153
B	PRO157

---

site_id	AD4
Number of Residues	16
Details	binding site for residue V6B C 401

Chain	Residue
C	ILE18
C	GLY19
C	ALA39
C	GLU92
C	MET94
C	ASP95
C	GLY96
C	ALA97
C	GLU102
C	LYS105
C	CYS146
C	LEU148
C	GLY161
C	GLY162
C	EDO402
C	HOH521

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO C 402

Chain	Residue
C	ALA97
C	ASP98
C	PHE101
C	V6B401
C	HOH570

---

site_id	AD6
Number of Residues	1
Details	binding site for residue EDO C 403

Chain	Residue
C	GLU13

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO C 404

Chain	Residue
C	ARG28
C	ILE30
D	ILE286
D	HIS287

---

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO C 405

Chain	Residue
C	ARG61
C	ILE167
C	GLN168
C	ARG225

---

site_id	AD9
Number of Residues	18
Details	binding site for residue V6B D 401

Chain	Residue
D	ILE18
D	GLY19
D	ALA39
D	VAL75
D	GLU92
D	PHE93
D	MET94
D	ASP95
D	GLY96
D	ALA97
D	GLU102
D	LYS105
D	CYS146
D	LEU148
D	GLY161
D	GLY162
D	EDO402
D	HOH517

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO D 402

Chain	Residue
D	ALA97
D	ASP98
D	PHE101
D	V6B401

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO D 403

Chain	Residue
D	ARG61
D	ILE167
D	GLN168
D	ARG225

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO D 404

Chain	Residue
C	HIS287
D	ARG28
D	ILE30

---

site_id	AE4
Number of Residues	2
Details	binding site for residue EDO D 405

Chain	Residue
C	LYS285
D	GLU13

---

site_id	AE5
Number of Residues	3
Details	binding site for residue EDO D 406

Chain	Residue
D	LYS41
D	GLY162
D	GLY164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1056
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00100","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"18423203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O70589","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---