Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue V6E A 401 |
| Chain | Residue |
| A | ILE18 |
| A | CYS146 |
| A | LEU148 |
| A | GLY161 |
| A | GLY162 |
| A | HOH517 |
| A | GLY19 |
| A | ALA39 |
| A | GLU92 |
| A | PHE93 |
| A | MET94 |
| A | ASP95 |
| A | GLY96 |
| A | LYS105 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | ARG28 |
| A | ILE30 |
| B | HIS287 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | SER24 |
| A | LYS41 |
| A | PHE48 |
| A | LEU59 |
| A | GLU62 |
| A | HOH605 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | CYS66 |
| A | ILE74 |
| A | VAL75 |
| A | LEU77 |
| A | PHE163 |
| A | HOH563 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ARG130 |
| A | ASP134 |
| A | TYR268 |
| A | HOH511 |
| A | HOH575 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | ASN136 |
| A | GLU171 |
| A | GLY173 |
| B | GLU247 |
| B | ASP251 |
| B | HOH558 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | LEU217 |
| A | TYR220 |
| A | HOH576 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue V6E B 401 |
| Chain | Residue |
| B | ILE18 |
| B | GLY19 |
| B | ALA39 |
| B | PHE91 |
| B | GLU92 |
| B | PHE93 |
| B | MET94 |
| B | ASP95 |
| B | GLY96 |
| B | LYS105 |
| B | CYS146 |
| B | LEU148 |
| B | GLY161 |
| B | GLY162 |
| B | HOH590 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| A | GLU247 |
| A | ASP251 |
| B | ASN136 |
| B | GLU171 |
| B | LYS198 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| A | VAL112 |
| A | HIS287 |
| B | ARG28 |
| B | ILE30 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | SER24 |
| B | LYS41 |
| B | VAL43 |
| B | GLU62 |
| B | HOH563 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | LYS70 |
| B | HIS71 |
| B | HOH507 |
| B | HOH551 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | PHE101 |
| B | HIS145 |
| B | ARG302 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | ALA97 |
| B | PHE101 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | LYS70 |
| B | CYS216 |
| B | LEU217 |
| B | TYR220 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| A | GLU269 |
| B | TYR235 |
| B | ARG254 |
| B | HOH514 |
| site_id | AD8 |
| Number of Residues | 14 |
| Details | binding site for residue V6E C 401 |
| Chain | Residue |
| C | LEU148 |
| C | GLY161 |
| C | GLY162 |
| C | HOH547 |
| C | ILE18 |
| C | GLY19 |
| C | ALA39 |
| C | GLU92 |
| C | MET94 |
| C | ASP95 |
| C | GLY96 |
| C | ALA97 |
| C | LYS105 |
| C | CYS146 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 402 |
| Chain | Residue |
| C | ARG28 |
| C | ILE30 |
| D | ILE286 |
| D | HIS287 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| C | SER24 |
| C | LYS41 |
| C | GLU62 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 404 |
| Chain | Residue |
| C | HIS120 |
| C | SER155 |
| C | HOH560 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | CYS216 |
| C | LEU217 |
| C | TYR220 |
| C | HOH561 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | TYR235 |
| C | ARG254 |
| D | GLU269 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue V6E D 401 |
| Chain | Residue |
| D | ILE18 |
| D | ALA39 |
| D | PHE91 |
| D | GLU92 |
| D | PHE93 |
| D | MET94 |
| D | ASP95 |
| D | GLY96 |
| D | LYS105 |
| D | CYS146 |
| D | LEU148 |
| D | GLY161 |
| D | GLY162 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 402 |
| Chain | Residue |
| C | VAL112 |
| C | HIS287 |
| D | ARG28 |
| D | ILE30 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| D | SER24 |
| D | LYS41 |
| D | VAL43 |
| D | PHE48 |
| D | GLU62 |
| D | HOH591 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 404 |
| Chain | Residue |
| C | GLU247 |
| C | HOH545 |
| D | ASN136 |
| D | GLY170 |
| D | GLU171 |
| D | GLY173 |
| D | LYS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1056 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00100","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"18423203","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O70589","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
