7O1M
Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme alpha-H462A, beta-C92A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003857 | molecular_function | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016509 | molecular_function | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016829 | molecular_function | lyase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009274 | cellular_component | peptidoglycan-based cell wall |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 501 |
| Chain | Residue |
| D | ARG195 |
| D | LEU201 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 502 |
| Chain | Residue |
| D | PRO193 |
| D | ARG195 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 503 |
| Chain | Residue |
| D | ASN380 |
| D | ARG402 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 504 |
| Chain | Residue |
| D | SER163 |
| D | ARG164 |
| D | ASN249 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 801 |
| Chain | Residue |
| A | GLY709 |
| A | ASP710 |
| A | ARG711 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | PRO259 |
| A | GLY293 |
| A | GLN294 |
| A | VAL295 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | VAL274 |
| A | ASP275 |
| D | HIS24 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 804 |
| Chain | Residue |
| A | PRO631 |
| A | LEU632 |
| D | HIS243 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10020","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20066036","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
