7NXZ

Synthetic glycoform of Human Interleukin 6

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0001781	biological_process	neutrophil apoptotic process
AAA	0002314	biological_process	germinal center B cell differentiation
AAA	0002384	biological_process	hepatic immune response
AAA	0002446	biological_process	neutrophil mediated immunity
AAA	0002548	biological_process	monocyte chemotaxis
AAA	0002639	biological_process	positive regulation of immunoglobulin production
AAA	0002675	biological_process	positive regulation of acute inflammatory response
AAA	0002690	biological_process	positive regulation of leukocyte chemotaxis
AAA	0005102	molecular_function	signaling receptor binding
AAA	0005125	molecular_function	cytokine activity
AAA	0005138	molecular_function	interleukin-6 receptor binding
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005615	cellular_component	extracellular space
AAA	0005788	cellular_component	endoplasmic reticulum lumen
AAA	0005896	cellular_component	interleukin-6 receptor complex
AAA	0006953	biological_process	acute-phase response
AAA	0006954	biological_process	inflammatory response
AAA	0006955	biological_process	immune response
AAA	0006959	biological_process	humoral immune response
AAA	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
AAA	0008083	molecular_function	growth factor activity
AAA	0008284	biological_process	positive regulation of cell population proliferation
AAA	0008285	biological_process	negative regulation of cell population proliferation
AAA	0010573	biological_process	vascular endothelial growth factor production
AAA	0010574	biological_process	regulation of vascular endothelial growth factor production
AAA	0010575	biological_process	positive regulation of vascular endothelial growth factor production
AAA	0010628	biological_process	positive regulation of gene expression
AAA	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
AAA	0010888	biological_process	negative regulation of lipid storage
AAA	0014823	biological_process	response to activity
AAA	0019221	biological_process	cytokine-mediated signaling pathway
AAA	0030154	biological_process	cell differentiation
AAA	0030168	biological_process	platelet activation
AAA	0031018	biological_process	endocrine pancreas development
AAA	0031175	biological_process	neuron projection development
AAA	0032494	biological_process	response to peptidoglycan
AAA	0032682	biological_process	negative regulation of chemokine production
AAA	0032722	biological_process	positive regulation of chemokine production
AAA	0032731	biological_process	positive regulation of interleukin-1 beta production
AAA	0032733	biological_process	positive regulation of interleukin-10 production
AAA	0032740	biological_process	positive regulation of interleukin-17 production
AAA	0032745	biological_process	positive regulation of interleukin-21 production
AAA	0032755	biological_process	positive regulation of interleukin-6 production
AAA	0032757	biological_process	positive regulation of interleukin-8 production
AAA	0032760	biological_process	positive regulation of tumor necrosis factor production
AAA	0032966	biological_process	negative regulation of collagen biosynthetic process
AAA	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
AAA	0035633	biological_process	maintenance of blood-brain barrier
AAA	0042102	biological_process	positive regulation of T cell proliferation
AAA	0042593	biological_process	glucose homeostasis
AAA	0042802	molecular_function	identical protein binding
AAA	0043065	biological_process	positive regulation of apoptotic process
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0043410	biological_process	positive regulation of MAPK cascade
AAA	0045599	biological_process	negative regulation of fat cell differentiation
AAA	0045669	biological_process	positive regulation of osteoblast differentiation
AAA	0045727	biological_process	positive regulation of translation
AAA	0045765	biological_process	regulation of angiogenesis
AAA	0045779	biological_process	negative regulation of bone resorption
AAA	0045893	biological_process	positive regulation of DNA-templated transcription
AAA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AAA	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
AAA	0048661	biological_process	positive regulation of smooth muscle cell proliferation
AAA	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
AAA	0050768	biological_process	negative regulation of neurogenesis
AAA	0050796	biological_process	regulation of insulin secretion
AAA	0050829	biological_process	defense response to Gram-negative bacterium
AAA	0050830	biological_process	defense response to Gram-positive bacterium
AAA	0050871	biological_process	positive regulation of B cell activation
AAA	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
AAA	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
AAA	0051240	biological_process	positive regulation of multicellular organismal process
AAA	0051384	biological_process	response to glucocorticoid
AAA	0051607	biological_process	defense response to virus
AAA	0060252	biological_process	positive regulation of glial cell proliferation
AAA	0061470	biological_process	T follicular helper cell differentiation
AAA	0061888	biological_process	regulation of astrocyte activation
AAA	0070050	biological_process	neuron cellular homeostasis
AAA	0070091	biological_process	glucagon secretion
AAA	0070092	biological_process	regulation of glucagon secretion
AAA	0070102	biological_process	interleukin-6-mediated signaling pathway
AAA	0070301	biological_process	cellular response to hydrogen peroxide
AAA	0071222	biological_process	cellular response to lipopolysaccharide
AAA	0072540	biological_process	T-helper 17 cell lineage commitment
AAA	0072574	biological_process	hepatocyte proliferation
AAA	0090091	biological_process	positive regulation of extracellular matrix disassembly
AAA	0090594	biological_process	inflammatory response to wounding
AAA	0097421	biological_process	liver regeneration
AAA	0097696	biological_process	cell surface receptor signaling pathway via STAT
AAA	0098586	biological_process	cellular response to virus
AAA	0150077	biological_process	regulation of neuroinflammatory response
AAA	0150078	biological_process	positive regulation of neuroinflammatory response
AAA	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
AAA	1901731	biological_process	positive regulation of platelet aggregation
AAA	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
AAA	1902895	biological_process	positive regulation of miRNA transcription
AAA	1903978	biological_process	regulation of microglial cell activation
AAA	1904894	biological_process	positive regulation of receptor signaling pathway via STAT
AAA	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
AAA	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
AAA	2000635	biological_process	negative regulation of primary miRNA processing
AAA	2000660	biological_process	negative regulation of interleukin-1-mediated signaling pathway
AAA	2000676	biological_process	positive regulation of type B pancreatic cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL

Chain	Residue	Details
AAA	CYS72-LEU97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
AAA	SER52

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1883960

Chain	Residue	Details
AAA	ASN44

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