7NVH

Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue AV0 A 801

Chain	Residue
A	GLN40
A	VAL169
A	THR174
A	ILE177
A	HIS234
A	TYR235
A	PHE236
A	ILE422
A	GLN437
A	ARG448
A	ASN450
A	SER41
A	GLU548
A	TYR44
A	VAL51
A	SER54
A	ASP58
A	ASP139
A	GLY165
A	LEU166

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	139
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:A0QP27

Chain	Residue	Details
A	MET1-ARG13
A	GLY207-PRO209
A	VAL257-THR286
A	LEU336-PRO396
A	PRO584-LYS586
A	SER638-ARG672

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PHE14-LEU34
A	PHE617-LEU637
A	ILE673-LEU693
A	LEU699-VAL719
A	VAL186-ALA206
A	VAL210-PHE230
A	PHE236-ILE256
A	PHE287-LEU307
A	ILE315-ILE335
A	VAL397-LEU417
A	VAL563-LEU583
A	ALA587-VAL607

---

site_id	SWS_FT_FI3
Number of Residues	316
Details	TOPO_DOM: Periplasmic => ECO:0000250|UniProtKB:A0QP27

Chain	Residue	Details
A	GLY35-GLU185
A	GLY231-TYR235
A	LYS308-THR314
A	SER418-MET562
A	ASP608-ASN616
A	VAL694-TYR698

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:A0QP27

Chain	Residue	Details
A	GLN40

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site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Part of the proton-transportation channel => ECO:0000250|UniProtKB:A0QP27

Chain	Residue	Details
A	ASP251
A	TYR252
A	ASP640
A	TYR641

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Part of the proton transportation network => ECO:0000250|UniProtKB:A0QP27

Chain	Residue	Details
A	LYS586
A	GLU642

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