7NPW

Cryo-EM structure of Human excitatory amino acid transporters-1 (EAAT1) in potassium buffer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015293	molecular_function	symporter activity
A	0016020	cellular_component	membrane
B	0015293	molecular_function	symporter activity
B	0016020	cellular_component	membrane
C	0015293	molecular_function	symporter activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	15
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GElLMrMLQMLVlP

Chain	Residue	Details
A	PRO84-PRO98

---

site_id	PS00714
Number of Residues	24
Details	NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaLaaIFIAQ

Chain	Residue	Details
A	PRO392-GLN415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	183
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	99
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	81
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	189
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28424515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O59010","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---