Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NNW

Crystal structure of Mycobacterium tuberculosis ArgF in complex with methyl 4-hydroxy-3-iodobenzoate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 401

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH526
A	HOH545
A	HOH548

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 B 401

Chain	Residue
B	ALA276
B	HOH579
E	GLY235
B	ASN248
B	SER249
B	THR274

site_id	AC3
Number of Residues	8
Details	binding site for residue 98T B 402

Chain	Residue
A	THR51
A	ARG52
A	PHE55
B	GLU82
B	THR87
B	VAL90
B	LEU91
B	TYR94

site_id	AC4
Number of Residues	4
Details	binding site for residue PO4 C 701

Chain	Residue
C	SER249
C	THR274
C	HOH827
C	HOH850

site_id	AC5
Number of Residues	6
Details	binding site for residue PO4 C 702

Chain	Residue
B	SER50
B	THR51
C	SER75
C	THR76
C	ASP81
C	HOH844

site_id	AC6
Number of Residues	6
Details	binding site for residue 98T C 703

Chain	Residue
A	LEU78
A	LEU91
A	TYR94
C	ARG52
C	PHE55
C	HOH991

site_id	AC7
Number of Residues	5
Details	binding site for residue 98T C 704

Chain	Residue
B	ARG52
B	PHE55
C	LEU78
C	LEU91
C	TYR94

site_id	AC8
Number of Residues	6
Details	binding site for residue PO4 D 501

Chain	Residue
D	ASN248
D	SER249
D	THR274
D	ALA276
D	HOH627
D	HOH659

site_id	AC9
Number of Residues	6
Details	binding site for residue 98T D 502

Chain	Residue
D	ARG52
D	PHE55
E	ILE45
E	LEU78
E	LEU91
E	TYR94

site_id	AD1
Number of Residues	7
Details	binding site for residue 98T D 503

Chain	Residue
D	LEU78
D	VAL90
D	LEU91
D	TYR94
D	HOH805
F	ARG52
F	PHE55

site_id	AD2
Number of Residues	5
Details	binding site for residue PO4 E 401

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH561
E	HOH579

site_id	AD3
Number of Residues	6
Details	binding site for residue 98T E 402

Chain	Residue
E	ARG52
E	PHE55
F	LEU78
F	THR87
F	LEU91
F	TYR94

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	BINDING: BINDING => ECO:0000269\|PubMed:18062991, ECO:0007744\|PDB:2I6U

Chain	Residue	Details
A	SER50
B	SER50
B	GLN77
B	ARG101
B	HIS128
B	ASN160
B	ASP224
B	SER228
B	CYS264
B	ARG292
C	SER50
A	GLN77
C	GLN77
C	ARG101
C	HIS128
C	ASN160
C	ASP224
C	SER228
C	CYS264
C	ARG292
D	SER50
D	GLN77
A	ARG101
D	ARG101
D	HIS128
D	ASN160
D	ASP224
D	SER228
D	CYS264
D	ARG292
E	SER50
E	GLN77
E	ARG101
A	HIS128
E	HIS128
E	ASN160
E	ASP224
E	SER228
E	CYS264
E	ARG292
F	SER50
F	GLN77
F	ARG101
F	HIS128
A	ASN160
F	ASN160
F	ASP224
F	SER228
F	CYS264
F	ARG292
A	ASP224
A	SER228
A	CYS264
A	ARG292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)