Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NNV

Crystal structure of Mycobacterium tuberculosis ArgF in complex with carbamoyl phosphate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 401

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH506
A	HOH564
A	HOH574

site_id	AC2
Number of Residues	12
Details	binding site for residue CP A 402

Chain	Residue
A	THR53
A	ARG101
A	HIS128
A	GLN131
A	CYS264
A	LEU265
A	ARG292
A	HOH647
A	HOH689
A	SER50
A	THR51
A	ARG52

site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 A 403

Chain	Residue
A	HIS212
A	ASN248
A	ARG250
A	LEU251
A	HOH515
A	HOH537

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO A 404

Chain	Residue
A	PHE46
A	ASP47
A	ASP72
A	SER73
A	SER75
A	THR76
A	GLN77
A	LEU78

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 405

Chain	Residue
A	ASN49
A	SER50
A	ARG54
A	ASP72
A	HOH535
B	SER75

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 B 401

Chain	Residue
B	ASN248
B	SER249
B	THR274
B	HOH569

site_id	AC7
Number of Residues	12
Details	binding site for residue CP B 402

Chain	Residue
B	SER50
B	THR51
B	ARG52
B	THR53
B	ARG101
B	HIS128
B	GLN131
B	CYS264
B	LEU265
B	ARG292
B	HOH614
B	HOH634

site_id	AC8
Number of Residues	6
Details	binding site for residue PO4 C 501

Chain	Residue
C	ASN248
C	SER249
C	THR274
C	HOH616
C	HOH677
C	HOH720

site_id	AC9
Number of Residues	12
Details	binding site for residue CP C 502

Chain	Residue
C	SER50
C	THR51
C	ARG52
C	THR53
C	ARG101
C	HIS128
C	GLN131
C	CYS264
C	LEU265
C	ARG292
C	HOH699
C	HOH723

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO C 503

Chain	Residue
C	ASP47
C	ASP72
C	SER73
C	SER75
C	THR76
C	GLN77
C	LEU78
C	HOH770

site_id	AD2
Number of Residues	6
Details	binding site for residue PO4 D 501

Chain	Residue
D	ASN248
D	SER249
D	THR274
D	HOH615
D	HOH678
D	HOH786

site_id	AD3
Number of Residues	12
Details	binding site for residue CP D 502

Chain	Residue
D	SER50
D	THR51
D	ARG52
D	THR53
D	ARG101
D	HIS128
D	GLN131
D	CYS264
D	LEU265
D	ARG292
D	HOH728
D	HOH736

site_id	AD4
Number of Residues	5
Details	binding site for residue PO4 D 503

Chain	Residue
D	ASN248
D	ARG250
D	LEU251
D	HOH766
D	HIS212

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO D 504

Chain	Residue
D	PHE46
D	ASP47
D	ASP72
D	SER73
D	SER75
D	THR76
D	GLN77
D	LEU78

site_id	AD6
Number of Residues	6
Details	binding site for residue PO4 E 501

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH639
E	HOH686
E	HOH725

site_id	AD7
Number of Residues	11
Details	binding site for residue CP E 502

Chain	Residue
E	SER50
E	THR51
E	ARG52
E	THR53
E	ARG101
E	HIS128
E	GLN131
E	CYS264
E	LEU265
E	ARG292
E	HOH743

site_id	AD8
Number of Residues	5
Details	binding site for residue PO4 E 503

Chain	Residue
E	HIS212
E	ASN248
E	ARG250
E	LEU251
E	HOH603

site_id	AD9
Number of Residues	8
Details	binding site for residue EDO E 504

Chain	Residue
E	PHE46
E	ASP47
E	ASP72
E	SER73
E	SER75
E	THR76
E	GLN77
E	LEU78

site_id	AE1
Number of Residues	5
Details	binding site for residue PO4 E 505

Chain	Residue
E	ARG191
E	GLU195
E	HOH615
E	HOH665
E	HOH705

site_id	AE2
Number of Residues	12
Details	binding site for residue CP F 401

Chain	Residue
F	SER50
F	THR51
F	ARG52
F	THR53
F	ARG101
F	HIS128
F	GLN131
F	CYS264
F	LEU265
F	ARG292
F	HOH618
F	HOH664

site_id	AE3
Number of Residues	8
Details	binding site for residue EDO F 402

Chain	Residue
F	ILE45
F	PHE46
F	ASP47
F	ASP72
F	SER73
F	SER75
F	GLN77
F	LEU78

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	BINDING: BINDING => ECO:0000269\|PubMed:18062991, ECO:0007744\|PDB:2I6U

Chain	Residue	Details
A	SER50
B	SER50
B	GLN77
B	ARG101
B	HIS128
B	ASN160
B	ASP224
B	SER228
B	CYS264
B	ARG292
C	SER50
A	GLN77
C	GLN77
C	ARG101
C	HIS128
C	ASN160
C	ASP224
C	SER228
C	CYS264
C	ARG292
D	SER50
D	GLN77
A	ARG101
D	ARG101
D	HIS128
D	ASN160
D	ASP224
D	SER228
D	CYS264
D	ARG292
E	SER50
E	GLN77
E	ARG101
A	HIS128
E	HIS128
E	ASN160
E	ASP224
E	SER228
E	CYS264
E	ARG292
F	SER50
F	GLN77
F	ARG101
F	HIS128
A	ASN160
F	ASN160
F	ASP224
F	SER228
F	CYS264
F	ARG292
A	ASP224
A	SER228
A	CYS264
A	ARG292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)