7NNQ
Crystal structure of Mycobacterium tuberculosis ArgC in complex with nicotinamide adenine dinucleotide phosphate (NADP+)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006526 | biological_process | arginine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0051287 | molecular_function | NAD binding |
A | 0070401 | molecular_function | NADP+ binding |
B | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006526 | biological_process | arginine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0051287 | molecular_function | NAD binding |
B | 0070401 | molecular_function | NADP+ binding |
C | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0006526 | biological_process | arginine biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0051287 | molecular_function | NAD binding |
C | 0070401 | molecular_function | NADP+ binding |
D | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0006526 | biological_process | arginine biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0051287 | molecular_function | NAD binding |
D | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 36 |
Details | binding site for residue NAP A 401 |
Chain | Residue |
A | GLY16 |
A | THR73 |
A | ALA87 |
A | LEU88 |
A | PRO89 |
A | HIS92 |
A | CYS109 |
A | GLY110 |
A | SER189 |
A | GLY190 |
A | GLY192 |
A | SER18 |
A | ARG193 |
A | ALA194 |
A | ASN320 |
A | LEU321 |
A | GLY324 |
A | THR325 |
A | HOH514 |
A | HOH523 |
A | HOH541 |
A | HOH555 |
A | GLY19 |
A | HOH556 |
A | HOH560 |
A | HOH566 |
A | HOH634 |
A | HOH672 |
A | HOH684 |
A | HOH697 |
A | TYR20 |
A | ALA21 |
A | ALA47 |
A | ALA48 |
A | THR49 |
A | SER50 |
site_id | AC2 |
Number of Residues | 38 |
Details | binding site for residue NAP B 401 |
Chain | Residue |
B | GLY16 |
B | SER18 |
B | GLY19 |
B | TYR20 |
B | ALA21 |
B | ALA47 |
B | ALA48 |
B | THR49 |
B | SER50 |
B | THR73 |
B | ALA87 |
B | LEU88 |
B | PRO89 |
B | HIS92 |
B | CYS109 |
B | GLY110 |
B | SER189 |
B | GLY190 |
B | GLY192 |
B | ARG193 |
B | ALA194 |
B | ASN320 |
B | LEU321 |
B | GLY324 |
B | THR325 |
B | HOH523 |
B | HOH541 |
B | HOH552 |
B | HOH558 |
B | HOH560 |
B | HOH579 |
B | HOH618 |
B | HOH619 |
B | HOH635 |
B | HOH638 |
B | HOH639 |
B | HOH656 |
B | HOH664 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue BTB B 402 |
Chain | Residue |
B | HIS32 |
B | ALA34 |
B | ASP37 |
B | ARG39 |
B | TRP339 |
B | PRO340 |
B | ASP343 |
site_id | AC4 |
Number of Residues | 34 |
Details | binding site for residue NAP C 401 |
Chain | Residue |
C | GLY192 |
C | ARG193 |
C | ALA194 |
C | ASN320 |
C | LEU321 |
C | GLY324 |
C | THR325 |
C | HOH513 |
C | HOH586 |
C | HOH591 |
C | HOH596 |
C | HOH609 |
C | HOH619 |
C | HOH624 |
C | HOH651 |
C | HOH658 |
C | GLY16 |
C | SER18 |
C | GLY19 |
C | TYR20 |
C | ALA21 |
C | ALA47 |
C | ALA48 |
C | THR49 |
C | SER50 |
C | THR73 |
C | ALA87 |
C | LEU88 |
C | PRO89 |
C | HIS92 |
C | CYS109 |
C | GLY110 |
C | SER189 |
C | GLY190 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue BTB C 402 |
Chain | Residue |
C | HIS32 |
C | ALA34 |
C | ASP37 |
C | ARG39 |
C | TRP339 |
C | ASP343 |
site_id | AC6 |
Number of Residues | 36 |
Details | binding site for residue NAP D 401 |
Chain | Residue |
D | GLY16 |
D | SER18 |
D | GLY19 |
D | TYR20 |
D | ALA21 |
D | ALA47 |
D | ALA48 |
D | THR49 |
D | SER50 |
D | THR73 |
D | ALA87 |
D | LEU88 |
D | PRO89 |
D | HIS92 |
D | CYS109 |
D | GLY110 |
D | ARG114 |
D | CYS158 |
D | SER189 |
D | GLY190 |
D | GLY192 |
D | ARG193 |
D | ALA194 |
D | ASN320 |
D | LEU321 |
D | GLY324 |
D | THR325 |
D | HOH525 |
D | HOH536 |
D | HOH543 |
D | HOH565 |
D | HOH601 |
D | HOH612 |
D | HOH643 |
D | HOH645 |
D | HOH652 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue BTB D 402 |
Chain | Residue |
D | HIS32 |
D | ALA34 |
D | ASP37 |
D | ARG39 |
D | TRP339 |
D | PRO340 |
D | ASP343 |
Functional Information from PROSITE/UniProt
site_id | PS01224 |
Number of Residues | 17 |
Details | ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP |
Chain | Residue | Details |
A | ILE153-PRO169 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00150 |
Chain | Residue | Details |
A | CYS158 | |
B | CYS158 | |
C | CYS158 | |
D | CYS158 |