7NMZ

Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AA	0002028	biological_process	regulation of sodium ion transport
AA	0003779	molecular_function	actin binding
AA	0005159	molecular_function	insulin-like growth factor receptor binding
AA	0005515	molecular_function	protein binding
AA	0005737	cellular_component	cytoplasm
AA	0005829	cellular_component	cytosol
AA	0005886	cellular_component	plasma membrane
AA	0006713	biological_process	glucocorticoid catabolic process
AA	0006886	biological_process	intracellular protein transport
AA	0007165	biological_process	signal transduction
AA	0008104	biological_process	protein localization
AA	0014704	cellular_component	intercalated disc
AA	0017080	molecular_function	sodium channel regulator activity
AA	0019899	molecular_function	enzyme binding
AA	0019904	molecular_function	protein domain specific binding
AA	0021762	biological_process	substantia nigra development
AA	0035259	molecular_function	nuclear glucocorticoid receptor binding
AA	0042802	molecular_function	identical protein binding
AA	0042921	biological_process	intracellular glucocorticoid receptor signaling pathway
AA	0044325	molecular_function	transmembrane transporter binding
AA	0045664	biological_process	regulation of neuron differentiation
AA	0045893	biological_process	positive regulation of DNA-templated transcription
AA	0046982	molecular_function	protein heterodimerization activity
AA	0048167	biological_process	regulation of synaptic plasticity
AA	0050774	biological_process	negative regulation of dendrite morphogenesis
AA	0070062	cellular_component	extracellular exosome
AA	0086010	biological_process	membrane depolarization during action potential
AA	0098793	cellular_component	presynapse
AA	0098978	cellular_component	glutamatergic synapse
AA	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
AA	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
AA	2000649	biological_process	regulation of sodium ion transmembrane transporter activity
BA	0002028	biological_process	regulation of sodium ion transport
BA	0003779	molecular_function	actin binding
BA	0005159	molecular_function	insulin-like growth factor receptor binding
BA	0005515	molecular_function	protein binding
BA	0005737	cellular_component	cytoplasm
BA	0005829	cellular_component	cytosol
BA	0005886	cellular_component	plasma membrane
BA	0006713	biological_process	glucocorticoid catabolic process
BA	0006886	biological_process	intracellular protein transport
BA	0007165	biological_process	signal transduction
BA	0008104	biological_process	protein localization
BA	0014704	cellular_component	intercalated disc
BA	0017080	molecular_function	sodium channel regulator activity
BA	0019899	molecular_function	enzyme binding
BA	0019904	molecular_function	protein domain specific binding
BA	0021762	biological_process	substantia nigra development
BA	0035259	molecular_function	nuclear glucocorticoid receptor binding
BA	0042802	molecular_function	identical protein binding
BA	0042921	biological_process	intracellular glucocorticoid receptor signaling pathway
BA	0044325	molecular_function	transmembrane transporter binding
BA	0045664	biological_process	regulation of neuron differentiation
BA	0045893	biological_process	positive regulation of DNA-templated transcription
BA	0046982	molecular_function	protein heterodimerization activity
BA	0048167	biological_process	regulation of synaptic plasticity
BA	0050774	biological_process	negative regulation of dendrite morphogenesis
BA	0070062	cellular_component	extracellular exosome
BA	0086010	biological_process	membrane depolarization during action potential
BA	0098793	cellular_component	presynapse
BA	0098978	cellular_component	glutamatergic synapse
BA	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
BA	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
BA	2000649	biological_process	regulation of sodium ion transmembrane transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
AA	ARG44-VAL54

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site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Weerkdakgrt.YYvnhnnrtTTWTRP

Chain	Residue	Details
C	TRP391-PRO416

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by WNK1 and WNK4 => ECO:0000269|PubMed:15328345, ECO:0000269|PubMed:20525693, ECO:0007744|PubMed:18669648

Chain	Residue	Details
AA	ARG134
C	SEP342
BA	ARG59
BA	ARG134

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by SGK1 => ECO:0000305|PubMed:15328345

Chain	Residue	Details
C	ALA367
BA	GLY4

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
BA	SER27
C	SER446

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA and SGK1 => ECO:0000269|PubMed:15328345, ECO:0000269|PubMed:15677482, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SEP448
BA	SER61

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by WNK1 and WNK4 => ECO:0000269|PubMed:20525693, ECO:0007744|PubMed:18669648

Chain	Residue	Details
C	SER449

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