7NLC

Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015031	biological_process	protein transport
A	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL A 201

Chain	Residue
A	ILE99

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 202

Chain	Residue
A	SER95

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLY102
A	LYS103
A	GLU140
A	NH4207
A	NH4208
A	NH4235

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NH4 A 204

Chain	Residue
A	NH4231
A	HOH314
A	HOH339
A	NH4210

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NH4 A 205

Chain	Residue
A	LYS100
A	NH4206
A	NH4207
A	NH4235

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NH4 A 206

Chain	Residue
A	GLU140
A	NH4205
A	NH4207
A	NH4208

---

site_id	AC7
Number of Residues	8
Details	binding site for residue NH4 A 207

Chain	Residue
A	GLY102
A	LYS103
A	HIS104
A	VAL105
A	SO4203
A	NH4205
A	NH4206
A	NH4208

---

site_id	AC8
Number of Residues	7
Details	binding site for residue NH4 A 208

Chain	Residue
A	HIS104
A	VAL136
A	GLU140
A	SO4203
A	NH4206
A	NH4207
A	HOH337

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NH4 A 209

Chain	Residue
A	VAL135
A	ASP139
A	NH4213
A	NH4237
B	HOH201

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NH4 A 210

Chain	Residue
A	PRO64
A	GLY138
A	NH4204
A	NH4211
A	NH4213

---

site_id	AD2
Number of Residues	4
Details	binding site for residue NH4 A 211

Chain	Residue
A	TYR65
A	ARG66
A	NH4210
A	NH4212

---

site_id	AD3
Number of Residues	4
Details	binding site for residue NH4 A 212

Chain	Residue
A	GLY138
A	ASP139
A	NH4211
A	NH4213

---

site_id	AD4
Number of Residues	5
Details	binding site for residue NH4 A 213

Chain	Residue
A	GLY138
A	ASP139
A	NH4209
A	NH4210
A	NH4212

---

site_id	AD5
Number of Residues	5
Details	binding site for residue NH4 A 214

Chain	Residue
A	PRO114
A	TYR115
A	VAL132
A	NH4215
A	NH4218

---

site_id	AD6
Number of Residues	4
Details	binding site for residue NH4 A 215

Chain	Residue
A	ASN68
A	NH4214
A	HOH338
A	HOH341

---

site_id	AD7
Number of Residues	3
Details	binding site for residue NH4 A 216

Chain	Residue
A	GLY67
A	NH4217
A	HOH341

---

site_id	AD8
Number of Residues	3
Details	binding site for residue NH4 A 217

Chain	Residue
A	TYR115
A	SER124
A	NH4216

---

site_id	AD9
Number of Residues	3
Details	binding site for residue NH4 A 218

Chain	Residue
A	NH4214
A	NH4247
A	HOH365

---

site_id	AE1
Number of Residues	4
Details	binding site for residue NH4 A 219

Chain	Residue
A	CYS89
A	ILE111
A	NH4249
A	HOH345

---

site_id	AE2
Number of Residues	4
Details	binding site for residue NH4 A 220

Chain	Residue
A	LEU79
A	PRO86
A	HOH324
A	HOH358

---

site_id	AE3
Number of Residues	4
Details	binding site for residue NH4 A 221

Chain	Residue
A	LEU79
A	ASN85
A	PRO86
A	PRO87

---

site_id	AE4
Number of Residues	2
Details	binding site for residue NH4 A 222

Chain	Residue
A	ARG52
A	ASP80

---

site_id	AE5
Number of Residues	5
Details	binding site for residue NH4 A 223

Chain	Residue
A	SER8
A	ASP106
A	ASN108
A	HOH304
A	HOH351

---

site_id	AE6
Number of Residues	3
Details	binding site for residue NH4 A 224

Chain	Residue
A	TRP77
A	PHE90
A	HOH309

---

site_id	AE7
Number of Residues	5
Details	binding site for residue NH4 A 225

Chain	Residue
A	GLY59
A	ILE74
A	NH4227
A	NH4236
A	THR58

---

site_id	AE8
Number of Residues	4
Details	binding site for residue NH4 A 226

Chain	Residue
A	LYS92
A	NH4236
A	HOH310
A	HOH347

---

site_id	AE9
Number of Residues	4
Details	binding site for residue NH4 A 227

Chain	Residue
A	GLY59
A	NH4225
A	HOH310
A	HOH330

---

site_id	AF1
Number of Residues	2
Details	binding site for residue NH4 A 228

Chain	Residue
A	LYS92
A	PRO93

---

site_id	AF2
Number of Residues	5
Details	binding site for residue NH4 A 229

Chain	Residue
A	PRO64
A	SER145
A	ARG146
A	NH4231
A	NH4237

---

site_id	AF3
Number of Residues	5
Details	binding site for residue NH4 A 230

Chain	Residue
A	THR98
A	PHE144
A	SER145
A	HOH306
A	HOH323

---

site_id	AF4
Number of Residues	6
Details	binding site for residue NH4 A 231

Chain	Residue
A	SER96
A	SER145
A	ARG146
A	NH4204
A	NH4229
A	HOH305

---

site_id	AF5
Number of Residues	3
Details	binding site for residue NH4 A 232

Chain	Residue
A	VAL91
A	LYS92
A	ASN108

---

site_id	AF6
Number of Residues	5
Details	binding site for residue NH4 A 233

Chain	Residue
A	ASP36
A	THR60
A	ILE61
A	PRO62
A	ASN71

---

site_id	AF7
Number of Residues	5
Details	binding site for residue NH4 A 234

Chain	Residue
A	TYR34
A	LYS35
A	ASP36
A	THR60
A	HOH317

---

site_id	AF8
Number of Residues	5
Details	binding site for residue NH4 A 235

Chain	Residue
A	LYS100
A	GLU140
A	SO4203
A	NH4205
A	HOH331

---

site_id	AF9
Number of Residues	3
Details	binding site for residue NH4 A 236

Chain	Residue
A	LYS92
A	NH4225
A	NH4226

---

site_id	AG1
Number of Residues	6
Details	binding site for residue NH4 A 237

Chain	Residue
A	PRO64
A	ILE134
A	VAL135
A	GLY138
A	NH4209
A	NH4229

---

site_id	AG2
Number of Residues	4
Details	binding site for residue NH4 A 238

Chain	Residue
A	THR81
A	TYR84
A	PRO86
A	TRP119

---

site_id	AG3
Number of Residues	4
Details	binding site for residue NH4 A 239

Chain	Residue
A	TYR65
A	ASN68
A	TYR70
A	GLN131

---

site_id	AG4
Number of Residues	1
Details	binding site for residue NH4 A 240

Chain	Residue
A	ILE31

---

site_id	AG5
Number of Residues	4
Details	binding site for residue NH4 A 241

Chain	Residue
A	GLU26
A	LEU126
A	LEU127
A	HOH328

---

site_id	AG6
Number of Residues	3
Details	binding site for residue NH4 A 242

Chain	Residue
A	THR69
A	ARG146
A	PRO147

---

site_id	AG7
Number of Residues	4
Details	binding site for residue NH4 A 243

Chain	Residue
A	GLY67
A	ASN68
A	THR69
A	ARG146

---

site_id	AG8
Number of Residues	3
Details	binding site for residue NH4 A 244

Chain	Residue
A	LEU33
A	LYS35
B	PRO10

---

site_id	AG9
Number of Residues	4
Details	binding site for residue NH4 A 245

Chain	Residue
A	VAL40
A	LEU41
A	HOH308
A	HOH329

---

site_id	AH1
Number of Residues	4
Details	binding site for residue NH4 A 246

Chain	Residue
A	TYR65
A	ARG66
A	GLN131
A	HOH357

---

site_id	AH2
Number of Residues	2
Details	binding site for residue NH4 A 247

Chain	Residue
A	HIS104
A	NH4218

---

site_id	AH3
Number of Residues	5
Details	binding site for residue NH4 A 248

Chain	Residue
A	TYR112
A	LEU113
A	NH4249
A	HOH303
A	HOH311

---

site_id	AH4
Number of Residues	5
Details	binding site for residue NH4 A 249

Chain	Residue
A	ILE111
A	TYR112
A	NH4219
A	NH4248
A	HOH313

---

site_id	AH5
Number of Residues	5
Details	binding site for residue NH4 A 250

Chain	Residue
A	TYR34
A	ILE134
A	PRO147
B	LEU8
B	PRO10

---

site_id	AH6
Number of Residues	5
Details	binding site for residue NH4 B 101

Chain	Residue
A	SER145
A	HOH305
B	SER4
B	ALA5
B	HOH201

---

site_id	AH7
Number of Residues	3
Details	binding site for residue NH4 B 102

Chain	Residue
A	LEU33
B	PRO9
B	PRO10

---

site_id	AH8
Number of Residues	4
Details	binding site for residue NH4 B 103

Chain	Residue
A	TYR34
A	GLN131
B	PRO7
B	PRO9

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	143
Details	Domain: {"description":"UEV","evidences":[{"source":"PROSITE-ProRule","id":"PRU00652","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"PTAP/PSAP motif","evidences":[{"source":"UniProtKB","id":"Q81870","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---