7NIV
Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005548 | molecular_function | phospholipid transporter activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030136 | cellular_component | clathrin-coated vesicle |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032376 | biological_process | positive regulation of cholesterol transport |
| A | 0032782 | biological_process | bile acid secretion |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0061092 | biological_process | positive regulation of phospholipid translocation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090554 | molecular_function | phosphatidylcholine floppase activity |
| A | 0099038 | molecular_function | ceramide floppase activity |
| A | 0099040 | biological_process | ceramide translocation |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1901557 | biological_process | response to fenofibrate |
| A | 1903413 | biological_process | cellular response to bile acid |
| A | 2001140 | biological_process | positive regulation of phospholipid transport |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL |
| Chain | Residue | Details |
| A | LEU533-LEU547 | |
| A | LEU1175-LEU1189 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| C | TYR214-HIS220 | |
| E | TYR207-HIS213 | |
| D | TYR193-HIS199 | |
| B | TYR193-HIS199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 247 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 218 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 57 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 288 |
| Details | Domain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31873305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6S7P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31873305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6S7P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
