7NAA

Crystal structure of Mycobacterium tuberculosis H37Rv PknF kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHrDVKpaNILI

Chain	Residue	Details
A	LEU133-ILE145

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP137
B	ASP137
C	ASP137
D	ASP137

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU18
A	LYS41
B	LEU18
B	LYS41
C	LEU18
C	LYS41
D	LEU18
D	LYS41

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site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:15967413

Chain	Residue	Details
A	THR8
C	THR13
C	THR173
C	THR175
D	THR8
D	THR13
D	THR173
D	THR175
A	THR13
A	THR173
A	THR175
B	THR8
B	THR13
B	THR173
B	THR175
C	THR8

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