7N73

Cryo-EM structure of ATP13A2 in the ADP-AlF-bound E1P-ADP-like state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000421	cellular_component	autophagosome membrane
A	0005215	molecular_function	transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005770	cellular_component	late endosome
A	0005771	cellular_component	multivesicular body
A	0005776	cellular_component	autophagosome
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0006914	biological_process	autophagy
A	0007041	biological_process	lysosomal transport
A	0008270	molecular_function	zinc ion binding
A	0008289	molecular_function	lipid binding
A	0010628	biological_process	positive regulation of gene expression
A	0010821	biological_process	regulation of mitochondrion organization
A	0012506	cellular_component	vesicle membrane
A	0015203	molecular_function	polyamine transmembrane transporter activity
A	0015417	molecular_function	ABC-type polyamine transporter activity
A	0015662	molecular_function	P-type ion transporter activity
A	0016020	cellular_component	membrane
A	0016241	biological_process	regulation of macroautophagy
A	0016243	biological_process	regulation of autophagosome size
A	0016887	molecular_function	ATP hydrolysis activity
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030003	biological_process	intracellular monoatomic cation homeostasis
A	0030133	cellular_component	transport vesicle
A	0030145	molecular_function	manganese ion binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0031982	cellular_component	vesicle
A	0032585	cellular_component	multivesicular body membrane
A	0033157	biological_process	regulation of intracellular protein transport
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034599	biological_process	cellular response to oxidative stress
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043202	cellular_component	lysosomal lumen
A	0043523	biological_process	regulation of neuron apoptotic process
A	0046872	molecular_function	metal ion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0055088	biological_process	lipid homeostasis
A	0061462	biological_process	protein localization to lysosome
A	0061909	biological_process	autophagosome-lysosome fusion
A	0070300	molecular_function	phosphatidic acid binding
A	0071287	biological_process	cellular response to manganese ion
A	0071294	biological_process	cellular response to zinc ion
A	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
A	0097734	biological_process	extracellular exosome biogenesis
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0140358	molecular_function	P-type transmembrane transporter activity
A	1900180	biological_process	regulation of protein localization to nucleus
A	1902047	biological_process	polyamine transmembrane transport
A	1903135	molecular_function	cupric ion binding
A	1903146	biological_process	regulation of autophagy of mitochondrion
A	1903543	biological_process	positive regulation of exosomal secretion
A	1903710	biological_process	spermine transmembrane transport
A	1904714	biological_process	regulation of chaperone-mediated autophagy
A	1905037	biological_process	autophagosome organization
A	1905165	biological_process	regulation of lysosomal protein catabolic process
A	1905166	biological_process	negative regulation of lysosomal protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP508-THR514

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site_id	PS01229
Number of Residues	23
Details	COF_2 Hypothetical cof family signature 2. CGDGaNDcgaLkaAdvGisLsqA

Chain	Residue	Details
A	CYS871-ALA893

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	196
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	68
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"26134396","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	175
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26134396","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"26134396","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26134396","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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