7N0D

Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0008270	molecular_function	zinc ion binding
A	0019079	biological_process	viral genome replication
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004532	molecular_function	RNA exonuclease activity
B	0008168	molecular_function	methyltransferase activity
C	0003723	molecular_function	RNA binding
C	0008270	molecular_function	zinc ion binding
C	0019079	biological_process	viral genome replication
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004532	molecular_function	RNA exonuclease activity
D	0008168	molecular_function	methyltransferase activity
E	0003723	molecular_function	RNA binding
E	0008270	molecular_function	zinc ion binding
E	0019079	biological_process	viral genome replication
F	0000175	molecular_function	3'-5'-RNA exonuclease activity
F	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
F	0004532	molecular_function	RNA exonuclease activity
F	0008168	molecular_function	methyltransferase activity
G	0003723	molecular_function	RNA binding
G	0008270	molecular_function	zinc ion binding
G	0019079	biological_process	viral genome replication
H	0000175	molecular_function	3'-5'-RNA exonuclease activity
H	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
H	0004532	molecular_function	RNA exonuclease activity
H	0008168	molecular_function	methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01297","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	860
Details	Domain: {"description":"ExoN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Region: {"description":"GpppA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36546776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---