7MXO
CryoEM structure of human NKCC1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
| Chain | Residue | Details |
| A | TRP287-GLY313 | |
| A | PHE487-ILE507 | |
| B | TRP287-GLY313 | |
| B | PHE487-ILE507 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | INTRAMEM: Helical => ECO:0000305|PubMed:32081947 |
| Chain | Residue | Details |
| A | TRP287-ILE299 | |
| A | LEU308-GLY313 | |
| A | PHE487-ALA498 | |
| A | ILE501-ILE507 | |
| B | TRP287-ILE299 | |
| B | LEU308-GLY313 | |
| B | PHE487-ALA498 | |
| B | ILE501-ILE507 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | INTRAMEM: INTRAMEM => ECO:0000305|PubMed:32081947 |
| Chain | Residue | Details |
| A | TRP300-ARG307 | |
| A | THR499-GLY500 | |
| B | TRP300-ARG307 | |
| B | THR499-GLY500 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 208 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
| Chain | Residue | Details |
| A | GLN314-VAL321 | |
| B | CYS543-PHE599 | |
| B | ALA669-GLU670 | |
| B | ASN731 | |
| A | HIS398-ILE406 | |
| A | ILE455-THR486 | |
| A | CYS543-PHE599 | |
| A | ALA669-GLU670 | |
| A | ASN731 | |
| B | GLN314-VAL321 | |
| B | HIS398-ILE406 | |
| B | ILE455-THR486 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 466 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
| Chain | Residue | Details |
| A | LEU322-THR343 | |
| A | TRP732-TYR751 | |
| B | LEU322-THR343 | |
| B | PRO362-GLU397 | |
| B | ASN407-SER424 | |
| B | TRP430-PHE454 | |
| B | GLN515-SER542 | |
| B | THR600-ASP632 | |
| B | GLY654-ILE668 | |
| B | LEU671-SER697 | |
| B | ASN712-ILE730 | |
| A | PRO362-GLU397 | |
| B | TRP732-TYR751 | |
| A | ASN407-SER424 | |
| A | TRP430-PHE454 | |
| A | GLN515-SER542 | |
| A | THR600-ASP632 | |
| A | GLY654-ILE668 | |
| A | LEU671-SER697 | |
| A | ASN712-ILE730 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 120 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714 |
| Chain | Residue | Details |
| A | ASN344-GLY361 | |
| B | LEU698-TYR711 | |
| A | VAL425-GLU429 | |
| A | SER508-PRO514 | |
| A | ASN633-ARG653 | |
| A | LEU698-TYR711 | |
| B | ASN344-GLY361 | |
| B | VAL425-GLU429 | |
| B | SER508-PRO514 | |
| B | ASN633-ARG653 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER940 | |
| A | SER994 | |
| B | SER940 | |
| B | SER994 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55012 |
| Chain | Residue | Details |
| A | SER944 | |
| B | SER944 |
