7MWF

HUWE1 in map with focus on interface

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000209	biological_process	protein polyubiquitination
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0007030	biological_process	Golgi organization
A	0010637	biological_process	negative regulation of mitochondrial fusion
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030154	biological_process	cell differentiation
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031965	cellular_component	nuclear membrane
A	0032922	biological_process	circadian regulation of gene expression
A	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
A	0034774	cellular_component	secretory granule lumen
A	0035359	biological_process	negative regulation of peroxisome proliferator activated receptor signaling pathway
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0048511	biological_process	rhythmic process
A	0061025	biological_process	membrane fusion
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
A	0140852	molecular_function	histone ubiquitin ligase activity
A	0141198	biological_process	protein branched polyubiquitination
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1905091	biological_process	positive regulation of type 2 mitophagy

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	77
Details	Domain: {"description":"WWE","evidences":[{"source":"PROSITE-ProRule","id":"PRU00248","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q7TMY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51593","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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