7MRV
F100A mutant structure of MIF2 (D-DT)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004167 | molecular_function | dopachrome isomerase activity |
| A | 0005126 | molecular_function | cytokine receptor binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0010760 | biological_process | negative regulation of macrophage chemotaxis |
| A | 0016829 | molecular_function | lyase activity |
| A | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| A | 0033981 | molecular_function | D-dopachrome decarboxylase activity |
| A | 0042438 | biological_process | melanin biosynthetic process |
| A | 0050178 | molecular_function | phenylpyruvate tautomerase activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | PRO1 |
| A | SER63 |
| A | ILE64 |
| A | TRP105 |
| A | HOH302 |
| A | HOH327 |
Functional Information from PROSITE/UniProt
| site_id | PS01158 |
| Number of Residues | 15 |
| Details | MIF Macrophage migration inhibitory factor family signature. EPCAqlsIsSIGvVG |
| Chain | Residue | Details |
| A | GLU54-GLY68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylproline => ECO:0000250|UniProtKB:O35215 |
| Chain | Residue | Details |
| A | PRO1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O35215 |
| Chain | Residue | Details |
| A | LYS32 |
