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7MOF

Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 6-diphosphoinositol 1,2,3,4,5-pentakisphosphate 6-InsP7

Functional Information from GO Data
ChainGOidnamespacecontents
A0006470biological_processprotein dephosphorylation
A0016791molecular_functionphosphatase activity
B0006470biological_processprotein dephosphorylation
B0016791molecular_functionphosphatase activity
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue ZKS A 501
ChainResidue
AGLY118
AARG156
ALYS186
AHOH601
AHOH601
AHOH601
AHOH630
AHOH660
AHOH680
AHOH699
AHOH699
ALYS120
AHOH699
AHOH722
ALYS120
ASER150
ALYS151
AARG152
AGLY153
ALYS154
AHIS155

site_idAC2
Number of Residues12
Detailsbinding site for residue IHP A 502
ChainResidue
AASN125
AILE126
APRO127
AHIS129
ALYS130
AHOH603
AHOH606
AHOH622
AHOH624
AHOH642
AHOH712
BLYS105

site_idAC3
Number of Residues23
Detailsbinding site for residue ZKS B 501
ChainResidue
BGLY118
BLYS120
BLYS120
BSER150
BLYS151
BARG152
BGLY153
BLYS154
BHIS155
BARG156
BLYS186
BHOH601
BHOH601
BHOH601
BHOH609
BHOH618
BHOH619
BHOH619
BHOH619
BHOH633
BHOH645
BHOH686
BHOH708

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ASER150
BSER150

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:7MOF
ChainResidueDetails
AASN125
AILE126
AHIS129
ALYS130
BASN125
BILE126
BHIS129
BLYS130

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Transition state stabilizer => ECO:0000250|UniProtKB:P53965
ChainResidueDetails
AARG156
BARG156

226707

PDB entries from 2024-10-30

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