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7MLS

X-ray crystal structure of human BRD4(D1) in complex with 2-(2,5-dibromophenoxy)-6-[4-methyl-1-(piperidin-4-yl)-1H-1,2,3-triazol-5-yl]pyridine (compound 23)

Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue ZHM A 201
ChainResidue
ATRP81
AHOH340
AHOH417
APRO82
ALYS99
AILE100
ATYR139
AASN140
AMET149
AHOH318
AHOH337

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH358

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 203
ChainResidue
ASER42
ALYS55
APRO56
ATRP120
AHOH406

site_idAC4
Number of Residues7
Detailsbinding site for residue CL A 204
ChainResidue
AVAL90
ALYS91
AASN93
ATYR137
AILE138
AASN140
AHOH446

site_idAC5
Number of Residues2
Detailsbinding site for residue CL A 205
ChainResidue
AARG58
AGLN59

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

219869

PDB entries from 2024-05-15

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