7MKH
Paired helical tau filament extracted from GSS Patient brain tissue | tau filament from Gerstmann Straussler Scheinker disease | PHF Tau
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0015631 | molecular_function | tubulin binding |
| B | 0008017 | molecular_function | microtubule binding |
| B | 0015631 | molecular_function | tubulin binding |
| C | 0008017 | molecular_function | microtubule binding |
| C | 0015631 | molecular_function | tubulin binding |
| D | 0008017 | molecular_function | microtubule binding |
| D | 0015631 | molecular_function | tubulin binding |
| E | 0008017 | molecular_function | microtubule binding |
| E | 0015631 | molecular_function | tubulin binding |
| F | 0008017 | molecular_function | microtubule binding |
| F | 0015631 | molecular_function | tubulin binding |
| G | 0008017 | molecular_function | microtubule binding |
| G | 0015631 | molecular_function | tubulin binding |
| H | 0008017 | molecular_function | microtubule binding |
| H | 0015631 | molecular_function | tubulin binding |
| I | 0008017 | molecular_function | microtubule binding |
| I | 0015631 | molecular_function | tubulin binding |
| J | 0008017 | molecular_function | microtubule binding |
| J | 0015631 | molecular_function | tubulin binding |
Functional Information from PROSITE/UniProt
| site_id | PS00229 |
| Number of Residues | 13 |
| Details | TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG |
| Chain | Residue | Details |
| A | GLY261-GLY273 | |
| A | GLY292-GLY304 | |
| A | GLY323-GLY335 | |
| A | GLY355-GLY367 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 300 |
| Details | Repeat: {"description":"Tau/MAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 310 |
| Details | Repeat: {"description":"Tau/MAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 70 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 60 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
