7MIV

Mouse CTPS2-I250T bound to inhibitor R80

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003883	molecular_function	CTP synthase activity
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
D	0003883	molecular_function	CTP synthase activity
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
G	0003883	molecular_function	CTP synthase activity
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
H	0003883	molecular_function	CTP synthase activity
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605

Chain	Residue	Details
D	CYS399
G	CYS399
G	HIS526
G	GLU528
D	HIS526
D	GLU528
C	CYS399
C	HIS526
C	GLU528
H	CYS399
H	HIS526
H	GLU528

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
D	SER568
G	SER568
G	SER571
G	SER574
D	SER571
D	SER574
C	SER568
C	SER571
C	SER574
H	SER568
H	SER571
H	SER574

---