7MIP

Mouse CTPS1 bound to inhibitor R80

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000785	cellular_component	chromatin
C	0003883	molecular_function	CTP synthase activity
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0032480	biological_process	negative regulation of type I interferon production
C	0042098	biological_process	T cell proliferation
C	0042100	biological_process	B cell proliferation
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
C	0140861	biological_process	DNA repair-dependent chromatin remodeling
C	0160260	molecular_function	protein asparagine deamidase activity
C	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
C	1902340	biological_process	negative regulation of chromosome condensation
D	0000785	cellular_component	chromatin
D	0003883	molecular_function	CTP synthase activity
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0042098	biological_process	T cell proliferation
D	0042100	biological_process	B cell proliferation
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0097268	cellular_component	cytoophidium
D	0140861	biological_process	DNA repair-dependent chromatin remodeling
D	0160260	molecular_function	protein asparagine deamidase activity
D	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
D	1902340	biological_process	negative regulation of chromosome condensation
G	0000785	cellular_component	chromatin
G	0003883	molecular_function	CTP synthase activity
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0032480	biological_process	negative regulation of type I interferon production
G	0042098	biological_process	T cell proliferation
G	0042100	biological_process	B cell proliferation
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0097268	cellular_component	cytoophidium
G	0140861	biological_process	DNA repair-dependent chromatin remodeling
G	0160260	molecular_function	protein asparagine deamidase activity
G	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
G	1902340	biological_process	negative regulation of chromosome condensation
I	0000785	cellular_component	chromatin
I	0003883	molecular_function	CTP synthase activity
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006241	biological_process	CTP biosynthetic process
I	0019856	biological_process	pyrimidine nucleobase biosynthetic process
I	0032480	biological_process	negative regulation of type I interferon production
I	0042098	biological_process	T cell proliferation
I	0042100	biological_process	B cell proliferation
I	0042802	molecular_function	identical protein binding
I	0044210	biological_process	'de novo' CTP biosynthetic process
I	0097268	cellular_component	cytoophidium
I	0140861	biological_process	DNA repair-dependent chromatin remodeling
I	0160260	molecular_function	protein asparagine deamidase activity
I	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
I	1902340	biological_process	negative regulation of chromosome condensation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For GATase and protein-asparagine deamidase activities","evidences":[{"source":"PubMed","id":"39719712","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P17812","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17812","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P17812","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17812","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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