7MIH

Human CTPS2 bound to inhibitor R80

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0019637	biological_process	organophosphate metabolic process
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
B	0019637	biological_process	organophosphate metabolic process
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
C	0019637	biological_process	organophosphate metabolic process
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
E	0003883	molecular_function	CTP synthase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0016874	molecular_function	ligase activity
E	0019637	biological_process	organophosphate metabolic process
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605

Chain	Residue	Details
A	CYS399
E	CYS399
E	HIS526
E	GLU528
A	HIS526
A	GLU528
B	CYS399
B	HIS526
B	GLU528
C	CYS399
C	HIS526
C	GLU528

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER568
B	SER568
C	SER568
E	SER568

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER571
B	SER571
C	SER571
E	SER571

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER574
B	SER574
C	SER574
E	SER574

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