7MIG

Human CTPS1 bound to inhibitor T35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0002376	biological_process	immune system process
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0032480	biological_process	negative regulation of type I interferon production
A	0042098	biological_process	T cell proliferation
A	0042100	biological_process	B cell proliferation
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0044281	biological_process	small molecule metabolic process
A	0097268	cellular_component	cytoophidium
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	0160260	molecular_function	protein asparagine deamidase activity
A	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
A	1902340	biological_process	negative regulation of chromosome condensation
B	0000166	molecular_function	nucleotide binding
B	0000785	cellular_component	chromatin
B	0002376	biological_process	immune system process
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0032480	biological_process	negative regulation of type I interferon production
B	0042098	biological_process	T cell proliferation
B	0042100	biological_process	B cell proliferation
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0044281	biological_process	small molecule metabolic process
B	0097268	cellular_component	cytoophidium
B	0140861	biological_process	DNA repair-dependent chromatin remodeling
B	0160260	molecular_function	protein asparagine deamidase activity
B	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
B	1902340	biological_process	negative regulation of chromosome condensation
C	0000166	molecular_function	nucleotide binding
C	0000785	cellular_component	chromatin
C	0002376	biological_process	immune system process
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006325	biological_process	chromatin organization
C	0006974	biological_process	DNA damage response
C	0009410	biological_process	response to xenobiotic stimulus
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0032480	biological_process	negative regulation of type I interferon production
C	0042098	biological_process	T cell proliferation
C	0042100	biological_process	B cell proliferation
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0044281	biological_process	small molecule metabolic process
C	0097268	cellular_component	cytoophidium
C	0140861	biological_process	DNA repair-dependent chromatin remodeling
C	0160260	molecular_function	protein asparagine deamidase activity
C	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
C	1902340	biological_process	negative regulation of chromosome condensation
E	0000166	molecular_function	nucleotide binding
E	0000785	cellular_component	chromatin
E	0002376	biological_process	immune system process
E	0003883	molecular_function	CTP synthase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006325	biological_process	chromatin organization
E	0006974	biological_process	DNA damage response
E	0009410	biological_process	response to xenobiotic stimulus
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0032480	biological_process	negative regulation of type I interferon production
E	0042098	biological_process	T cell proliferation
E	0042100	biological_process	B cell proliferation
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0044281	biological_process	small molecule metabolic process
E	0097268	cellular_component	cytoophidium
E	0140861	biological_process	DNA repair-dependent chromatin remodeling
E	0160260	molecular_function	protein asparagine deamidase activity
E	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
E	1902340	biological_process	negative regulation of chromosome condensation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For GATase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---