7MIG

Human CTPS1 bound to inhibitor T35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0016020	cellular_component	membrane
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042098	biological_process	T cell proliferation
A	0042100	biological_process	B cell proliferation
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0002376	biological_process	immune system process
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0009410	biological_process	response to xenobiotic stimulus
B	0016020	cellular_component	membrane
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042098	biological_process	T cell proliferation
B	0042100	biological_process	B cell proliferation
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0002376	biological_process	immune system process
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0009410	biological_process	response to xenobiotic stimulus
C	0016020	cellular_component	membrane
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042098	biological_process	T cell proliferation
C	0042100	biological_process	B cell proliferation
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
E	0002376	biological_process	immune system process
E	0003883	molecular_function	CTP synthase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0009410	biological_process	response to xenobiotic stimulus
E	0016020	cellular_component	membrane
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042098	biological_process	T cell proliferation
E	0042100	biological_process	B cell proliferation
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000250

Chain	Residue	Details
C	CYS399
E	CYS399
E	HIS526
E	GLU528
C	HIS526
C	GLU528
A	CYS399
A	HIS526
A	GLU528
B	CYS399
B	HIS526
B	GLU528

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS100
A	LYS100
B	LYS100
E	LYS100

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	SER562
A	SER562
B	SER562
E	SER562

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
C	SER568
C	SER587
A	SER568
A	SER587
B	SER568
B	SER587
E	SER568
E	SER587

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
C	SER571
A	SER571
B	SER571
E	SER571

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	SER573
A	SER573
B	SER573
E	SER573

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	SER574
A	SER574
B	SER574
E	SER574

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER575
A	SER575
B	SER575
E	SER575

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70698

Chain	Residue	Details
C	SER578
A	SER578
B	SER578
E	SER578

---