7MGE

Structure of C9orf72:SMCR8:WDR41 in complex with ARF1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0006914	biological_process	autophagy
A	0010506	biological_process	regulation of autophagy
A	0032045	cellular_component	guanyl-nucleotide exchange factor complex
A	0045920	biological_process	negative regulation of exocytosis
A	0050777	biological_process	negative regulation of immune response
B	0000785	cellular_component	chromatin
B	0004860	molecular_function	protein kinase inhibitor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0006914	biological_process	autophagy
B	0010506	biological_process	regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0016242	biological_process	negative regulation of macroautophagy
B	0019901	molecular_function	protein kinase binding
B	0032008	biological_process	positive regulation of TOR signaling
B	0032045	cellular_component	guanyl-nucleotide exchange factor complex
B	0045920	biological_process	negative regulation of exocytosis
B	0050777	biological_process	negative regulation of immune response
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	1901098	biological_process	positive regulation of autophagosome maturation
B	1902902	biological_process	negative regulation of autophagosome assembly
B	1903432	biological_process	regulation of TORC1 signaling
B	1990316	cellular_component	Atg1/ULK1 kinase complex
C	0000932	cellular_component	P-body
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006897	biological_process	endocytosis
C	0006914	biological_process	autophagy
C	0010494	cellular_component	cytoplasmic stress granule
C	0010506	biological_process	regulation of autophagy
C	0016239	biological_process	positive regulation of macroautophagy
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0032045	cellular_component	guanyl-nucleotide exchange factor complex
C	0032880	biological_process	regulation of protein localization
C	0034063	biological_process	stress granule assembly
C	0043005	cellular_component	neuron projection
C	0043204	cellular_component	perikaryon
C	0044295	cellular_component	axonal growth cone
C	0044304	cellular_component	main axon
C	0044754	cellular_component	autolysosome
C	0048675	biological_process	axon extension
C	0061909	biological_process	autophagosome-lysosome fusion
C	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
C	0098693	biological_process	regulation of synaptic vesicle cycle
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099523	cellular_component	presynaptic cytosol
C	0110053	biological_process	regulation of actin filament organization
C	1902774	biological_process	late endosome to lysosome transport
C	1903432	biological_process	regulation of TORC1 signaling
C	1990316	cellular_component	Atg1/ULK1 kinase complex
C	2000785	biological_process	regulation of autophagosome assembly
E	0000139	cellular_component	Golgi membrane
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0002090	biological_process	regulation of receptor internalization
E	0003723	molecular_function	RNA binding
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006878	biological_process	intracellular copper ion homeostasis
E	0006886	biological_process	intracellular protein transport
E	0012505	cellular_component	endomembrane system
E	0014069	cellular_component	postsynaptic density
E	0015031	biological_process	protein transport
E	0016192	biological_process	vesicle-mediated transport
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030017	cellular_component	sarcomere
E	0031252	cellular_component	cell leading edge
E	0032991	cellular_component	protein-containing complex
E	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
E	0043005	cellular_component	neuron projection
E	0045202	cellular_component	synapse
E	0060292	biological_process	long-term synaptic depression
E	0070062	cellular_component	extracellular exosome
E	0097061	biological_process	dendritic spine organization
E	0098586	biological_process	cellular response to virus
E	1990386	biological_process	mitotic cleavage furrow ingression

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ILTAsaDrTVIVWDG

Chain	Residue	Details
A	ILE106-GLY120
A	LEU337-LEU351

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Repeat: {"description":"WD 4"}

Chain

Residue

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site_id	SWS_FT_FI2
Number of Residues	38
Details	Repeat: {"description":"WD 6"}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by TBK1","evidences":[{"source":"PubMed","id":"27103069","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14690595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}

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Residue

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