7MEX
Structure of yeast Ubr1 in complex with Ubc2 and N-degron
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000151 | cellular_component | ubiquitin ligase complex |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006513 | biological_process | protein monoubiquitination |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008540 | cellular_component | proteasome regulatory particle, base subcomplex |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034620 | biological_process | cellular response to unfolded protein |
| A | 0036503 | biological_process | ERAD pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0071596 | biological_process | ubiquitin-dependent protein catabolic process via the N-end rule pathway |
| A | 0071629 | biological_process | cytoplasm protein quality control by the ubiquitin-proteasome system |
| A | 0072671 | biological_process | mitochondria-associated ubiquitin-dependent protein catabolic process |
| A | 0090089 | biological_process | regulation of dipeptide transport |
| A | 0120174 | biological_process | stress-induced homeostatically regulated protein degradation pathway |
| A | 1904855 | molecular_function | proteasome regulatory particle binding |
| A | 1990116 | biological_process | ribosome-associated ubiquitin-dependent protein catabolic process |
| A | 1990303 | cellular_component | UBR1-RAD6 ubiquitin ligase complex |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 146 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34789879","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by SGV1","evidences":[{"source":"PubMed","id":"16307922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 73 |
| Details | Zinc finger: {"description":"UBR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00508","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 104 |
| Details | Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PubMed","id":"34789879","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Region: {"description":"Ubiquitin-binding loop","evidences":[{"source":"PubMed","id":"34789879","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 332 |
| Details | Region: {"description":"Cap helical domain (CHD)","evidences":[{"source":"PubMed","id":"34789879","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34789879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MEY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
