7MDL

High-resolution crystal structure of human SepSecS-tRNASec complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0001514	biological_process	selenocysteine incorporation
A	0001717	biological_process	conversion of seryl-tRNAsec to selenocys-tRNAsec
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0016740	molecular_function	transferase activity
A	0098621	molecular_function	O-phosphoseryl-tRNA(Sec) selenium transferase activity
B	0000049	molecular_function	tRNA binding
B	0001514	biological_process	selenocysteine incorporation
B	0001717	biological_process	conversion of seryl-tRNAsec to selenocys-tRNAsec
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0016740	molecular_function	transferase activity
B	0098621	molecular_function	O-phosphoseryl-tRNA(Sec) selenium transferase activity
C	0000049	molecular_function	tRNA binding
C	0001514	biological_process	selenocysteine incorporation
C	0001717	biological_process	conversion of seryl-tRNAsec to selenocys-tRNAsec
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0016740	molecular_function	transferase activity
C	0098621	molecular_function	O-phosphoseryl-tRNA(Sec) selenium transferase activity
D	0000049	molecular_function	tRNA binding
D	0001514	biological_process	selenocysteine incorporation
D	0001717	biological_process	conversion of seryl-tRNAsec to selenocys-tRNAsec
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0016740	molecular_function	transferase activity
D	0098621	molecular_function	O-phosphoseryl-tRNA(Sec) selenium transferase activity

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. DIIKLAGVHTV

Chain	Residue	Details
A	ASP124-VAL134

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:19608919

Chain	Residue	Details
A	ARG75
A	ARG97
A	SER98
A	GLN105
A	ARG271
A	ARG313
A	ARG398
A	LYS463
B	ARG75
B	ARG97
B	SER98
B	GLN105
B	ARG271
B	ARG313
B	ARG398
B	LYS463
C	ARG75
C	ARG97
C	SER98
C	GLN105
C	ARG271
C	ARG313
C	ARG398
C	LYS463
D	ARG75
D	ARG97
D	SER98
D	GLN105
D	ARG271
D	ARG313
D	ARG398
D	LYS463

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate => ECO:0000250|UniProtKB:Q6P6M7

Chain	Residue	Details
A	GLU74
B	GLU74
C	GLU74
D	GLU74

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER14
B	SER14
C	SER14
D	SER14

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:19608919

Chain	Residue	Details
A	LYS284
B	LYS284
C	LYS284
D	LYS284

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