7MBG
SARS-CoV-2 Main protease in orthorhombic space group
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 401 |
| Chain | Residue |
| A | MET6 |
| A | ARG298 |
| A | GLN299 |
| A | DMS404 |
| B | TYR118 |
| B | SER123 |
| B | HOH531 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 402 |
| Chain | Residue |
| A | LYS97 |
| A | HOH510 |
| A | GLY15 |
| A | MET17 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 403 |
| Chain | Residue |
| A | MET165 |
| A | GLU166 |
| A | PRO168 |
| A | GLN189 |
| A | THR190 |
| A | GLN192 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 404 |
| Chain | Residue |
| A | MET6 |
| A | ALA7 |
| A | GLN127 |
| A | ARG298 |
| A | DMS401 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 405 |
| Chain | Residue |
| A | LEU141 |
| A | SER144 |
| A | HIS163 |
| A | GLU166 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 406 |
| Chain | Residue |
| A | HIS41 |
| A | TYR54 |
| A | ASP187 |
| A | GLN189 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue DMS A 407 |
| Chain | Residue |
| A | GLN19 |
| A | GLN69 |
| A | ALA70 |
| A | GLY71 |
| A | ASN119 |
| A | GLY120 |
| A | SER121 |
| A | HOH510 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 401 |
| Chain | Residue |
| B | MET6 |
| B | GLN127 |
| B | ASP295 |
| B | ARG298 |
| B | HOH557 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 402 |
| Chain | Residue |
| B | PHE3 |
| B | ARG4 |
| B | LEU282 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 403 |
| Chain | Residue |
| A | PRO184 |
| A | VAL186 |
| A | ARG188 |
| B | LYS100 |
| B | TYR101 |
| B | HOH503 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 404 |
| Chain | Residue |
| B | PHE140 |
| B | LEU141 |
| B | ASN142 |
| B | SER144 |
| B | HIS163 |
| B | MET165 |
| B | GLU166 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 405 |
| Chain | Residue |
| B | ALA70 |
| B | VAL73 |
| B | PRO96 |
| B | HOH569 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 406 |
| Chain | Residue |
| B | VAL212 |
| B | THR257 |
| B | HOH560 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 407 |
| Chain | Residue |
| B | MET165 |
| B | ASP187 |
| B | ARG188 |
| B | GLN189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
