7M4M
Crystal structure of RBR E3 ligase RNF216 with ubiquitin
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| C | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| C | ARG54 | |
| C | ARG72 | |
| D | ARG54 | |
| D | ARG72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| C | HIS68 | |
| D | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| C | SER65 | |
| D | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| C | THR66 | |
| D | THR66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| C | GLY76 | |
| A | CYS636 | |
| A | HIS643 | |
| A | CYS648 | |
| A | CYS675 | |
| A | CYS678 | |
| A | CYS693 | |
| A | CYS695 | |
| A | CYS700 | |
| A | CYS703 | |
| A | HIS716 | |
| D | GLY76 | |
| A | CYS724 | |
| B | CYS515 | |
| B | CYS518 | |
| B | CYS537 | |
| B | CYS540 | |
| B | CYS605 | |
| B | CYS608 | |
| B | CYS623 | |
| B | CYS628 | |
| B | CYS633 | |
| A | CYS537 | |
| B | CYS636 | |
| B | HIS643 | |
| B | CYS648 | |
| B | CYS675 | |
| B | CYS678 | |
| B | CYS693 | |
| B | CYS695 | |
| B | CYS700 | |
| B | CYS703 | |
| B | HIS716 | |
| A | CYS540 | |
| B | CYS724 | |
| A | CYS605 | |
| A | CYS608 | |
| A | CYS623 | |
| A | CYS628 | |
| A | CYS633 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| C | LYS6 | |
| D | LYS6 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| A | LYS619 | |
| B | LYS773 | |
| C | GLY76 | |
| A | LYS666 | |
| D | GLY76 | |
| A | LYS773 | |
| B | LYS619 | |
| B | LYS666 | |
| B | LYS765 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| C | LYS11 | |
| C | LYS48 | |
| D | LYS11 | |
| D | LYS48 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| C | LYS27 | |
| D | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| C | LYS29 | |
| D | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| C | LYS33 | |
| D | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| C | LYS63 | |
| D | LYS63 |
