7M1X
Cryo-EM Structure of Nucleosome containing mouse histone variant H2A.Z
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000786 | cellular_component | nucleosome |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0030527 | molecular_function | structural constituent of chromatin |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0000786 | cellular_component | nucleosome |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005694 | cellular_component | chromosome |
| B | 0006334 | biological_process | nucleosome assembly |
| B | 0030527 | molecular_function | structural constituent of chromatin |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| C | 0000786 | cellular_component | nucleosome |
| C | 0000791 | cellular_component | euchromatin |
| C | 0000792 | cellular_component | heterochromatin |
| C | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| C | 0000979 | molecular_function | RNA polymerase II core promoter sequence-specific DNA binding |
| C | 0001740 | cellular_component | Barr body |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0006325 | biological_process | chromatin organization |
| C | 0030527 | molecular_function | structural constituent of chromatin |
| C | 0031490 | molecular_function | chromatin DNA binding |
| C | 0031492 | molecular_function | nucleosomal DNA binding |
| C | 0031507 | biological_process | heterochromatin formation |
| C | 0032869 | biological_process | cellular response to insulin stimulus |
| C | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| C | 0046982 | molecular_function | protein heterodimerization activity |
| C | 0071392 | biological_process | cellular response to estradiol stimulus |
| D | 0000786 | cellular_component | nucleosome |
| D | 0003677 | molecular_function | DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005694 | cellular_component | chromosome |
| D | 0030527 | molecular_function | structural constituent of chromatin |
| D | 0046982 | molecular_function | protein heterodimerization activity |
| E | 0000786 | cellular_component | nucleosome |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005694 | cellular_component | chromosome |
| E | 0030527 | molecular_function | structural constituent of chromatin |
| E | 0046982 | molecular_function | protein heterodimerization activity |
| F | 0000786 | cellular_component | nucleosome |
| F | 0003677 | molecular_function | DNA binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005694 | cellular_component | chromosome |
| F | 0006334 | biological_process | nucleosome assembly |
| F | 0030527 | molecular_function | structural constituent of chromatin |
| F | 0046982 | molecular_function | protein heterodimerization activity |
| G | 0000786 | cellular_component | nucleosome |
| G | 0000791 | cellular_component | euchromatin |
| G | 0000792 | cellular_component | heterochromatin |
| G | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| G | 0000979 | molecular_function | RNA polymerase II core promoter sequence-specific DNA binding |
| G | 0001740 | cellular_component | Barr body |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005694 | cellular_component | chromosome |
| G | 0006325 | biological_process | chromatin organization |
| G | 0030527 | molecular_function | structural constituent of chromatin |
| G | 0031490 | molecular_function | chromatin DNA binding |
| G | 0031492 | molecular_function | nucleosomal DNA binding |
| G | 0031507 | biological_process | heterochromatin formation |
| G | 0032869 | biological_process | cellular response to insulin stimulus |
| G | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| G | 0046982 | molecular_function | protein heterodimerization activity |
| G | 0071392 | biological_process | cellular response to estradiol stimulus |
| H | 0000786 | cellular_component | nucleosome |
| H | 0003677 | molecular_function | DNA binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005694 | cellular_component | chromosome |
| H | 0030527 | molecular_function | structural constituent of chromatin |
| H | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| C | ALA823-VAL829 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| B | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| A | LYS414-LEU420 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| D | ARG1289-GLY1311 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| A | PRO466-ILE474 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT6 => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | ARG402 | |
| E | ARG602 | |
| D | LYS1212 | |
| D | LYS1217 | |
| H | LYS1402 | |
| H | LYS1409 | |
| H | LYS1412 | |
| H | LYS1417 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | THR403 | |
| E | THR603 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | LYS404 | |
| E | LYS604 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| A | GLN405 | |
| E | GLN605 | |
| H | LYS1517 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | THR406 | |
| A | THR411 | |
| E | THR606 | |
| E | THR611 | |
| F | LYS208 | |
| F | LYS216 | |
| F | LYS244 | |
| F | LYS279 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methylated lysine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | LYS409 | |
| A | LYS464 | |
| E | LYS609 | |
| E | LYS664 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | SER410 | |
| E | SER610 | |
| F | LYS231 | |
| F | LYS291 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| A | LYS414 | |
| E | LYS614 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | ARG417 | |
| E | ARG617 | |
| F | TYR251 | |
| F | TYR288 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-methylated lysine; alternate => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | LYS418 | |
| A | LYS427 | |
| A | LYS436 | |
| E | LYS618 | |
| E | LYS627 | |
| E | LYS636 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| A | LYS423 | |
| E | LYS623 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | TYR441 | |
| E | TYR641 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84244 |
| Chain | Residue | Details |
| A | LYS456 | |
| A | LYS479 | |
| E | LYS656 | |
| E | LYS679 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | SER457 | |
| E | SER657 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | THR480 | |
| E | THR680 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | LYS515 | |
| E | LYS715 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| A | LYS522 | |
| E | LYS722 |
