Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7M1M

Crystal structure of Pseudomonas aeruginosa ClpP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0044010	biological_process	single-species biofilm formation
A	0044011	biological_process	single-species biofilm formation on inanimate substrate
A	0051117	molecular_function	ATPase binding
A	0071236	biological_process	cellular response to antibiotic
A	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0044010	biological_process	single-species biofilm formation
B	0044011	biological_process	single-species biofilm formation on inanimate substrate
B	0051117	molecular_function	ATPase binding
B	0071236	biological_process	cellular response to antibiotic
B	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0044010	biological_process	single-species biofilm formation
C	0044011	biological_process	single-species biofilm formation on inanimate substrate
C	0051117	molecular_function	ATPase binding
C	0071236	biological_process	cellular response to antibiotic
C	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0044010	biological_process	single-species biofilm formation
D	0044011	biological_process	single-species biofilm formation on inanimate substrate
D	0051117	molecular_function	ATPase binding
D	0071236	biological_process	cellular response to antibiotic
D	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0044010	biological_process	single-species biofilm formation
E	0044011	biological_process	single-species biofilm formation on inanimate substrate
E	0051117	molecular_function	ATPase binding
E	0071236	biological_process	cellular response to antibiotic
E	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0044010	biological_process	single-species biofilm formation
F	0044011	biological_process	single-species biofilm formation on inanimate substrate
F	0051117	molecular_function	ATPase binding
F	0071236	biological_process	cellular response to antibiotic
F	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0044010	biological_process	single-species biofilm formation
G	0044011	biological_process	single-species biofilm formation on inanimate substrate
G	0051117	molecular_function	ATPase binding
G	0071236	biological_process	cellular response to antibiotic
G	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0044010	biological_process	single-species biofilm formation
H	0044011	biological_process	single-species biofilm formation on inanimate substrate
H	0051117	molecular_function	ATPase binding
H	0071236	biological_process	cellular response to antibiotic
H	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0044010	biological_process	single-species biofilm formation
I	0044011	biological_process	single-species biofilm formation on inanimate substrate
I	0051117	molecular_function	ATPase binding
I	0071236	biological_process	cellular response to antibiotic
I	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0044010	biological_process	single-species biofilm formation
J	0044011	biological_process	single-species biofilm formation on inanimate substrate
J	0051117	molecular_function	ATPase binding
J	0071236	biological_process	cellular response to antibiotic
J	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0044010	biological_process	single-species biofilm formation
K	0044011	biological_process	single-species biofilm formation on inanimate substrate
K	0051117	molecular_function	ATPase binding
K	0071236	biological_process	cellular response to antibiotic
K	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0044010	biological_process	single-species biofilm formation
L	0044011	biological_process	single-species biofilm formation on inanimate substrate
L	0051117	molecular_function	ATPase binding
L	0071236	biological_process	cellular response to antibiotic
L	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0044010	biological_process	single-species biofilm formation
M	0044011	biological_process	single-species biofilm formation on inanimate substrate
M	0051117	molecular_function	ATPase binding
M	0071236	biological_process	cellular response to antibiotic
M	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0044010	biological_process	single-species biofilm formation
N	0044011	biological_process	single-species biofilm formation on inanimate substrate
N	0051117	molecular_function	ATPase binding
N	0071236	biological_process	cellular response to antibiotic
N	0071978	biological_process	bacterial-type flagellum-dependent swarming motility

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MPD A 301

Chain	Residue
A	SER99
A	MET100
A	HIS124
A	LEU155

site_id	AC2
Number of Residues	4
Details	binding site for residue MPD B 301

Chain	Residue
A	LEU4
B	PHE32
B	HOH401
B	HOH403

site_id	AC3
Number of Residues	6
Details	binding site for residue MPD B 302

Chain	Residue
B	MET100
B	ILE123
B	HIS124
B	PRO126
B	LEU151
B	SER99

site_id	AC4
Number of Residues	4
Details	binding site for residue MPD C 301

Chain	Residue
B	LEU4
C	TYR22
C	PHE32
C	VAL34

site_id	AC5
Number of Residues	5
Details	binding site for residue MPD C 302

Chain	Residue
C	SER99
C	MET100
C	ILE123
C	HIS124
C	LEU151

site_id	AC6
Number of Residues	6
Details	binding site for residue MPD D 301

Chain	Residue
D	SER99
D	MET100
D	ILE123
D	HIS124
D	LEU151
D	LEU155

site_id	AC7
Number of Residues	5
Details	binding site for residue MPD E 301

Chain	Residue
E	SER99
E	MET100
E	ILE123
E	HIS124
E	LEU155

site_id	AC8
Number of Residues	5
Details	binding site for residue MPD F 301

Chain	Residue
F	SER99
F	MET100
F	ILE123
F	HIS124
F	LEU155

site_id	AC9
Number of Residues	4
Details	binding site for residue MPD G 301

Chain	Residue
G	SER99
G	ILE123
G	HIS124
G	LEU155

site_id	AD1
Number of Residues	5
Details	binding site for residue MPD H 301

Chain	Residue
H	SER99
H	MET100
H	ILE123
H	HIS124
H	LEU151

site_id	AD2
Number of Residues	5
Details	binding site for residue MPD I 301

Chain	Residue
I	SER99
I	ILE123
I	HIS124
I	LEU151
I	LEU155

site_id	AD3
Number of Residues	5
Details	binding site for residue MPD J 301

Chain	Residue
J	LEU4
K	TYR22
K	PHE32
K	VAL34
K	HOH413

site_id	AD4
Number of Residues	5
Details	binding site for residue MPD J 302

Chain	Residue
J	SER99
J	MET100
J	HIS124
J	LEU151
J	LEU155

site_id	AD5
Number of Residues	6
Details	binding site for residue MPD K 301

Chain	Residue
K	SER99
K	MET100
K	ILE123
K	HIS124
K	PRO126
K	LEU151

site_id	AD6
Number of Residues	7
Details	binding site for residue MPD L 301

Chain	Residue
L	SER99
L	MET100
L	ILE123
L	HIS124
L	PRO126
L	LEU151
L	LEU155

site_id	AD7
Number of Residues	5
Details	binding site for residue MPD M 301

Chain	Residue
M	TYR22
M	PHE32
M	HOH403
M	HOH411
M	HOH415

site_id	AD8
Number of Residues	6
Details	binding site for residue MPD M 302

Chain	Residue
M	SER99
M	MET100
M	HIS124
M	PRO126
M	LEU151
M	LEU155

site_id	AD9
Number of Residues	5
Details	binding site for residue MPD N 301

Chain	Residue
N	SER99
N	MET100
N	ILE123
N	HIS124
N	LEU151

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TtcIGqACSMGA

Chain	Residue	Details
A	THR91-ALA102

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyclPhsrMMIHQP

Chain	Residue	Details
A	ARG113-PRO126

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	SER99
J	SER99
K	SER99
L	SER99
M	SER99
N	SER99
B	SER99
C	SER99
D	SER99
E	SER99
F	SER99
G	SER99
H	SER99
I	SER99

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	HIS124
J	HIS124
K	HIS124
L	HIS124
M	HIS124
N	HIS124
B	HIS124
C	HIS124
D	HIS124
E	HIS124
F	HIS124
G	HIS124
H	HIS124
I	HIS124

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)