7LW1
Human phosphofructokinase-1 liver type bound to activator NA-11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003872 | molecular_function | 6-phosphofructokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005945 | cellular_component | 6-phosphofructokinase complex |
| A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0009749 | biological_process | response to glucose |
| A | 0016020 | cellular_component | membrane |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019900 | molecular_function | kinase binding |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046676 | biological_process | negative regulation of insulin secretion |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048029 | molecular_function | monosaccharide binding |
| A | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0070061 | molecular_function | fructose binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070095 | molecular_function | fructose-6-phosphate binding |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 0003872 | molecular_function | 6-phosphofructokinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005945 | cellular_component | 6-phosphofructokinase complex |
| D | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0009749 | biological_process | response to glucose |
| D | 0016020 | cellular_component | membrane |
| D | 0016208 | molecular_function | AMP binding |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016310 | biological_process | phosphorylation |
| D | 0019900 | molecular_function | kinase binding |
| D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046676 | biological_process | negative regulation of insulin secretion |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048029 | molecular_function | monosaccharide binding |
| D | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| D | 0061621 | biological_process | canonical glycolysis |
| D | 0070061 | molecular_function | fructose binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0070095 | molecular_function | fructose-6-phosphate binding |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 0003872 | molecular_function | 6-phosphofructokinase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0005945 | cellular_component | 6-phosphofructokinase complex |
| E | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| E | 0006096 | biological_process | glycolytic process |
| E | 0009749 | biological_process | response to glucose |
| E | 0016020 | cellular_component | membrane |
| E | 0016208 | molecular_function | AMP binding |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016310 | biological_process | phosphorylation |
| E | 0019900 | molecular_function | kinase binding |
| E | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| E | 0034774 | cellular_component | secretory granule lumen |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046676 | biological_process | negative regulation of insulin secretion |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0048029 | molecular_function | monosaccharide binding |
| E | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| E | 0061621 | biological_process | canonical glycolysis |
| E | 0070061 | molecular_function | fructose binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0070095 | molecular_function | fructose-6-phosphate binding |
| E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| F | 0003872 | molecular_function | 6-phosphofructokinase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0005945 | cellular_component | 6-phosphofructokinase complex |
| F | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| F | 0006096 | biological_process | glycolytic process |
| F | 0009749 | biological_process | response to glucose |
| F | 0016020 | cellular_component | membrane |
| F | 0016208 | molecular_function | AMP binding |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016310 | biological_process | phosphorylation |
| F | 0019900 | molecular_function | kinase binding |
| F | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| F | 0034774 | cellular_component | secretory granule lumen |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046676 | biological_process | negative regulation of insulin secretion |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0048029 | molecular_function | monosaccharide binding |
| F | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| F | 0061621 | biological_process | canonical glycolysis |
| F | 0070061 | molecular_function | fructose binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0070095 | molecular_function | fructose-6-phosphate binding |
| F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue YG1 A 801 |
| Chain | Residue |
| A | MET174 |
| A | TYR578 |
| A | PHE670 |
| A | TRP740 |
| A | LEU744 |
| A | ASP179 |
| A | PHE308 |
| A | ILE311 |
| A | LYS315 |
| A | ASN341 |
| A | PHE537 |
| A | ASP542 |
| A | VAL545 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue FBP A 802 |
| Chain | Residue |
| A | ALA409 |
| A | ARG470 |
| A | THR527 |
| A | SER529 |
| A | MET572 |
| A | GLU628 |
| A | HIS660 |
| A | GLN663 |
| A | ARG734 |
| D | ARG565 |
| D | ARG654 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue F6P A 803 |
| Chain | Residue |
| A | ILE165 |
| A | ASP166 |
| A | MET208 |
| A | GLU264 |
| A | HIS298 |
| A | ARG301 |
| D | ARG201 |
| D | ARG292 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue ADP A 804 |
| Chain | Residue |
| A | GLY24 |
| A | ARG88 |
| A | CYS89 |
| A | PHE92 |
| A | THR93 |
| A | GLY118 |
| A | GLY120 |
| A | SER121 |
| A | GLY124 |
| A | ILE127 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue YG1 D 801 |
| Chain | Residue |
| D | MET174 |
| D | ASP179 |
| D | PHE308 |
| D | ILE311 |
| D | LYS315 |
| D | ASN341 |
| D | PHE537 |
| D | ASP542 |
| D | VAL545 |
| D | TYR578 |
| D | PHE670 |
| D | TRP740 |
| D | LEU744 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue FBP D 802 |
| Chain | Residue |
| A | ARG565 |
| A | ARG654 |
| D | ALA409 |
| D | ARG470 |
| D | THR527 |
| D | SER529 |
| D | MET572 |
| D | GLU628 |
| D | HIS660 |
| D | GLN663 |
| D | ARG734 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue F6P D 803 |
| Chain | Residue |
| A | ARG201 |
| A | ARG292 |
| D | ILE165 |
| D | ASP166 |
| D | MET208 |
| D | GLU264 |
| D | HIS298 |
| D | ARG301 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue ADP D 804 |
| Chain | Residue |
| D | GLY24 |
| D | ARG88 |
| D | CYS89 |
| D | PHE92 |
| D | THR93 |
| D | GLY118 |
| D | GLY120 |
| D | SER121 |
| D | GLY124 |
| D | ILE127 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue YG1 E 801 |
| Chain | Residue |
| E | MET174 |
| E | ASP179 |
| E | PHE308 |
| E | ILE311 |
| E | LYS315 |
| E | ASN341 |
| E | PHE537 |
| E | ASP542 |
| E | VAL545 |
| E | TYR578 |
| E | PHE670 |
| E | TRP740 |
| E | LEU744 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue FBP E 802 |
| Chain | Residue |
| E | THR527 |
| E | SER529 |
| E | MET572 |
| E | GLU628 |
| E | HIS660 |
| E | GLN663 |
| E | ARG734 |
| F | ARG565 |
| F | ARG654 |
| E | ALA409 |
| E | ARG470 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue F6P E 803 |
| Chain | Residue |
| E | ILE165 |
| E | ASP166 |
| E | MET208 |
| E | GLU264 |
| E | HIS298 |
| E | ARG301 |
| F | ARG201 |
| F | ARG292 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue ADP E 804 |
| Chain | Residue |
| E | GLY24 |
| E | ARG88 |
| E | CYS89 |
| E | PHE92 |
| E | THR93 |
| E | GLY118 |
| E | GLY120 |
| E | SER121 |
| E | GLY124 |
| E | ILE127 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue YG1 F 801 |
| Chain | Residue |
| F | MET174 |
| F | ASP179 |
| F | PHE308 |
| F | ILE311 |
| F | LYS315 |
| F | ASN341 |
| F | PHE537 |
| F | ASP542 |
| F | VAL545 |
| F | TYR578 |
| F | PHE670 |
| F | TRP740 |
| F | LEU744 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for residue FBP F 802 |
| Chain | Residue |
| E | ARG565 |
| E | ARG654 |
| F | ALA409 |
| F | ARG470 |
| F | THR527 |
| F | SER529 |
| F | MET572 |
| F | GLU628 |
| F | HIS660 |
| F | GLN663 |
| F | ARG734 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue F6P F 803 |
| Chain | Residue |
| E | ARG201 |
| E | ARG292 |
| F | ILE165 |
| F | ASP166 |
| F | MET208 |
| F | GLU264 |
| F | HIS298 |
| F | ARG301 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue ADP F 804 |
| Chain | Residue |
| F | GLY24 |
| F | ARG88 |
| F | CYS89 |
| F | PHE92 |
| F | THR93 |
| F | GLY118 |
| F | GLY120 |
| F | SER121 |
| F | GLY124 |
| F | ILE127 |
Functional Information from PROSITE/UniProt
| site_id | PS00433 |
| Number of Residues | 19 |
| Details | PHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtvlGHvQRGGtpsafDR |
| Chain | Residue | Details |
| A | ARG292-ARG310 | |
| A | ARG654-ARG672 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | ASP166 | |
| D | ASP166 | |
| E | ASP166 | |
| F | ASP166 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | GLY25 | |
| D | ARG88 | |
| D | GLY118 | |
| D | ASP119 | |
| D | ARG201 | |
| D | ARG292 | |
| D | ARG565 | |
| D | ARG654 | |
| E | GLY25 | |
| E | ARG88 | |
| E | GLY118 | |
| A | ARG88 | |
| E | ASP119 | |
| E | ARG201 | |
| E | ARG292 | |
| E | ARG565 | |
| E | ARG654 | |
| F | GLY25 | |
| F | ARG88 | |
| F | GLY118 | |
| F | ASP119 | |
| F | ARG201 | |
| A | GLY118 | |
| F | ARG292 | |
| F | ARG565 | |
| F | ARG654 | |
| A | ASP119 | |
| A | ARG201 | |
| A | ARG292 | |
| A | ARG565 | |
| A | ARG654 | |
| D | GLY25 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | SER164 | |
| A | ARG734 | |
| D | SER164 | |
| D | MET208 | |
| D | GLU264 | |
| D | HIS298 | |
| D | ARG470 | |
| D | THR527 | |
| D | MET572 | |
| D | GLU628 | |
| D | HIS660 | |
| A | MET208 | |
| D | ARG734 | |
| E | SER164 | |
| E | MET208 | |
| E | GLU264 | |
| E | HIS298 | |
| E | ARG470 | |
| E | THR527 | |
| E | MET572 | |
| E | GLU628 | |
| E | HIS660 | |
| A | GLU264 | |
| E | ARG734 | |
| F | SER164 | |
| F | MET208 | |
| F | GLU264 | |
| F | HIS298 | |
| F | ARG470 | |
| F | THR527 | |
| F | MET572 | |
| F | GLU628 | |
| F | HIS660 | |
| A | HIS298 | |
| F | ARG734 | |
| A | ARG470 | |
| A | THR527 | |
| A | MET572 | |
| A | GLU628 | |
| A | HIS660 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47857 |
| Chain | Residue | Details |
| A | SER377 | |
| D | SER377 | |
| E | SER377 | |
| F | SER377 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P12382 |
| Chain | Residue | Details |
| A | TYR640 | |
| D | TYR640 | |
| E | TYR640 | |
| F | TYR640 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER775 | |
| D | SER775 | |
| E | SER775 | |
| F | SER775 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22923583 |
| Chain | Residue | Details |
| A | SER529 | |
| D | SER529 | |
| E | SER529 | |
| F | SER529 |
