7LW1
Human phosphofructokinase-1 liver type bound to activator NA-11
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003872 | molecular_function | 6-phosphofructokinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005945 | cellular_component | 6-phosphofructokinase complex |
A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
A | 0006096 | biological_process | glycolytic process |
A | 0009749 | biological_process | response to glucose |
A | 0016020 | cellular_component | membrane |
A | 0016208 | molecular_function | AMP binding |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0019900 | molecular_function | kinase binding |
A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0042802 | molecular_function | identical protein binding |
A | 0046676 | biological_process | negative regulation of insulin secretion |
A | 0046872 | molecular_function | metal ion binding |
A | 0048029 | molecular_function | monosaccharide binding |
A | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
A | 0061621 | biological_process | canonical glycolysis |
A | 0070061 | molecular_function | fructose binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070095 | molecular_function | fructose-6-phosphate binding |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
D | 0003872 | molecular_function | 6-phosphofructokinase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005945 | cellular_component | 6-phosphofructokinase complex |
D | 0006002 | biological_process | fructose 6-phosphate metabolic process |
D | 0006096 | biological_process | glycolytic process |
D | 0009749 | biological_process | response to glucose |
D | 0016020 | cellular_component | membrane |
D | 0016208 | molecular_function | AMP binding |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0019900 | molecular_function | kinase binding |
D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
D | 0034774 | cellular_component | secretory granule lumen |
D | 0042802 | molecular_function | identical protein binding |
D | 0046676 | biological_process | negative regulation of insulin secretion |
D | 0046872 | molecular_function | metal ion binding |
D | 0048029 | molecular_function | monosaccharide binding |
D | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
D | 0061621 | biological_process | canonical glycolysis |
D | 0070061 | molecular_function | fructose binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070095 | molecular_function | fructose-6-phosphate binding |
D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
E | 0003872 | molecular_function | 6-phosphofructokinase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0005945 | cellular_component | 6-phosphofructokinase complex |
E | 0006002 | biological_process | fructose 6-phosphate metabolic process |
E | 0006096 | biological_process | glycolytic process |
E | 0009749 | biological_process | response to glucose |
E | 0016020 | cellular_component | membrane |
E | 0016208 | molecular_function | AMP binding |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0019900 | molecular_function | kinase binding |
E | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
E | 0034774 | cellular_component | secretory granule lumen |
E | 0042802 | molecular_function | identical protein binding |
E | 0046676 | biological_process | negative regulation of insulin secretion |
E | 0046872 | molecular_function | metal ion binding |
E | 0048029 | molecular_function | monosaccharide binding |
E | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
E | 0061621 | biological_process | canonical glycolysis |
E | 0070061 | molecular_function | fructose binding |
E | 0070062 | cellular_component | extracellular exosome |
E | 0070095 | molecular_function | fructose-6-phosphate binding |
E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
F | 0003872 | molecular_function | 6-phosphofructokinase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0005945 | cellular_component | 6-phosphofructokinase complex |
F | 0006002 | biological_process | fructose 6-phosphate metabolic process |
F | 0006096 | biological_process | glycolytic process |
F | 0009749 | biological_process | response to glucose |
F | 0016020 | cellular_component | membrane |
F | 0016208 | molecular_function | AMP binding |
F | 0016301 | molecular_function | kinase activity |
F | 0016310 | biological_process | phosphorylation |
F | 0019900 | molecular_function | kinase binding |
F | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
F | 0034774 | cellular_component | secretory granule lumen |
F | 0042802 | molecular_function | identical protein binding |
F | 0046676 | biological_process | negative regulation of insulin secretion |
F | 0046872 | molecular_function | metal ion binding |
F | 0048029 | molecular_function | monosaccharide binding |
F | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
F | 0061621 | biological_process | canonical glycolysis |
F | 0070061 | molecular_function | fructose binding |
F | 0070062 | cellular_component | extracellular exosome |
F | 0070095 | molecular_function | fructose-6-phosphate binding |
F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue YG1 A 801 |
Chain | Residue |
A | MET174 |
A | TYR578 |
A | PHE670 |
A | TRP740 |
A | LEU744 |
A | ASP179 |
A | PHE308 |
A | ILE311 |
A | LYS315 |
A | ASN341 |
A | PHE537 |
A | ASP542 |
A | VAL545 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue FBP A 802 |
Chain | Residue |
A | ALA409 |
A | ARG470 |
A | THR527 |
A | SER529 |
A | MET572 |
A | GLU628 |
A | HIS660 |
A | GLN663 |
A | ARG734 |
D | ARG565 |
D | ARG654 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue F6P A 803 |
Chain | Residue |
A | ILE165 |
A | ASP166 |
A | MET208 |
A | GLU264 |
A | HIS298 |
A | ARG301 |
D | ARG201 |
D | ARG292 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue ADP A 804 |
Chain | Residue |
A | GLY24 |
A | ARG88 |
A | CYS89 |
A | PHE92 |
A | THR93 |
A | GLY118 |
A | GLY120 |
A | SER121 |
A | GLY124 |
A | ILE127 |
site_id | AC5 |
Number of Residues | 13 |
Details | binding site for residue YG1 D 801 |
Chain | Residue |
D | MET174 |
D | ASP179 |
D | PHE308 |
D | ILE311 |
D | LYS315 |
D | ASN341 |
D | PHE537 |
D | ASP542 |
D | VAL545 |
D | TYR578 |
D | PHE670 |
D | TRP740 |
D | LEU744 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue FBP D 802 |
Chain | Residue |
A | ARG565 |
A | ARG654 |
D | ALA409 |
D | ARG470 |
D | THR527 |
D | SER529 |
D | MET572 |
D | GLU628 |
D | HIS660 |
D | GLN663 |
D | ARG734 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue F6P D 803 |
Chain | Residue |
A | ARG201 |
A | ARG292 |
D | ILE165 |
D | ASP166 |
D | MET208 |
D | GLU264 |
D | HIS298 |
D | ARG301 |
site_id | AC8 |
Number of Residues | 10 |
Details | binding site for residue ADP D 804 |
Chain | Residue |
D | GLY24 |
D | ARG88 |
D | CYS89 |
D | PHE92 |
D | THR93 |
D | GLY118 |
D | GLY120 |
D | SER121 |
D | GLY124 |
D | ILE127 |
site_id | AC9 |
Number of Residues | 13 |
Details | binding site for residue YG1 E 801 |
Chain | Residue |
E | MET174 |
E | ASP179 |
E | PHE308 |
E | ILE311 |
E | LYS315 |
E | ASN341 |
E | PHE537 |
E | ASP542 |
E | VAL545 |
E | TYR578 |
E | PHE670 |
E | TRP740 |
E | LEU744 |
site_id | AD1 |
Number of Residues | 11 |
Details | binding site for residue FBP E 802 |
Chain | Residue |
E | THR527 |
E | SER529 |
E | MET572 |
E | GLU628 |
E | HIS660 |
E | GLN663 |
E | ARG734 |
F | ARG565 |
F | ARG654 |
E | ALA409 |
E | ARG470 |
site_id | AD2 |
Number of Residues | 8 |
Details | binding site for residue F6P E 803 |
Chain | Residue |
E | ILE165 |
E | ASP166 |
E | MET208 |
E | GLU264 |
E | HIS298 |
E | ARG301 |
F | ARG201 |
F | ARG292 |
site_id | AD3 |
Number of Residues | 10 |
Details | binding site for residue ADP E 804 |
Chain | Residue |
E | GLY24 |
E | ARG88 |
E | CYS89 |
E | PHE92 |
E | THR93 |
E | GLY118 |
E | GLY120 |
E | SER121 |
E | GLY124 |
E | ILE127 |
site_id | AD4 |
Number of Residues | 13 |
Details | binding site for residue YG1 F 801 |
Chain | Residue |
F | MET174 |
F | ASP179 |
F | PHE308 |
F | ILE311 |
F | LYS315 |
F | ASN341 |
F | PHE537 |
F | ASP542 |
F | VAL545 |
F | TYR578 |
F | PHE670 |
F | TRP740 |
F | LEU744 |
site_id | AD5 |
Number of Residues | 11 |
Details | binding site for residue FBP F 802 |
Chain | Residue |
E | ARG565 |
E | ARG654 |
F | ALA409 |
F | ARG470 |
F | THR527 |
F | SER529 |
F | MET572 |
F | GLU628 |
F | HIS660 |
F | GLN663 |
F | ARG734 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue F6P F 803 |
Chain | Residue |
E | ARG201 |
E | ARG292 |
F | ILE165 |
F | ASP166 |
F | MET208 |
F | GLU264 |
F | HIS298 |
F | ARG301 |
site_id | AD7 |
Number of Residues | 10 |
Details | binding site for residue ADP F 804 |
Chain | Residue |
F | GLY24 |
F | ARG88 |
F | CYS89 |
F | PHE92 |
F | THR93 |
F | GLY118 |
F | GLY120 |
F | SER121 |
F | GLY124 |
F | ILE127 |
Functional Information from PROSITE/UniProt
site_id | PS00433 |
Number of Residues | 19 |
Details | PHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtvlGHvQRGGtpsafDR |
Chain | Residue | Details |
A | ARG292-ARG310 | |
A | ARG654-ARG672 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | ASP166 | |
D | ASP166 | |
E | ASP166 | |
F | ASP166 |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | GLY25 | |
D | ARG88 | |
D | GLY118 | |
D | ASP119 | |
D | ARG201 | |
D | ARG292 | |
D | ARG565 | |
D | ARG654 | |
E | GLY25 | |
E | ARG88 | |
E | GLY118 | |
A | ARG88 | |
E | ASP119 | |
E | ARG201 | |
E | ARG292 | |
E | ARG565 | |
E | ARG654 | |
F | GLY25 | |
F | ARG88 | |
F | GLY118 | |
F | ASP119 | |
F | ARG201 | |
A | GLY118 | |
F | ARG292 | |
F | ARG565 | |
F | ARG654 | |
A | ASP119 | |
A | ARG201 | |
A | ARG292 | |
A | ARG565 | |
A | ARG654 | |
D | GLY25 |
site_id | SWS_FT_FI3 |
Number of Residues | 40 |
Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | SER164 | |
A | ARG734 | |
D | SER164 | |
D | MET208 | |
D | GLU264 | |
D | HIS298 | |
D | ARG470 | |
D | THR527 | |
D | MET572 | |
D | GLU628 | |
D | HIS660 | |
A | MET208 | |
D | ARG734 | |
E | SER164 | |
E | MET208 | |
E | GLU264 | |
E | HIS298 | |
E | ARG470 | |
E | THR527 | |
E | MET572 | |
E | GLU628 | |
E | HIS660 | |
A | GLU264 | |
E | ARG734 | |
F | SER164 | |
F | MET208 | |
F | GLU264 | |
F | HIS298 | |
F | ARG470 | |
F | THR527 | |
F | MET572 | |
F | GLU628 | |
F | HIS660 | |
A | HIS298 | |
F | ARG734 | |
A | ARG470 | |
A | THR527 | |
A | MET572 | |
A | GLU628 | |
A | HIS660 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | ALA2 | |
D | ALA2 | |
E | ALA2 | |
F | ALA2 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47857 |
Chain | Residue | Details |
A | SER377 | |
D | SER377 | |
E | SER377 | |
F | SER377 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P12382 |
Chain | Residue | Details |
A | TYR640 | |
D | TYR640 | |
E | TYR640 | |
F | TYR640 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER775 | |
D | SER775 | |
E | SER775 | |
F | SER775 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22923583 |
Chain | Residue | Details |
A | SER529 | |
D | SER529 | |
E | SER529 | |
F | SER529 |