7LSY

NHEJ Short-range synaptic complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000723	biological_process	telomere maintenance
A	0000725	biological_process	recombinational repair
A	0000781	cellular_component	chromosome, telomeric region
A	0000783	cellular_component	nuclear telomere cap complex
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0002684	biological_process	positive regulation of immune system process
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003691	molecular_function	double-stranded telomeric DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006351	biological_process	DNA-templated transcription
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0010212	biological_process	response to ionizing radiation
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030332	molecular_function	cyclin binding
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034774	cellular_component	secretory granule lumen
A	0042162	molecular_function	telomeric DNA binding
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0043564	cellular_component	Ku70:Ku80 complex
A	0044877	molecular_function	protein-containing complex binding
A	0045027	molecular_function	DNA end binding
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0070419	cellular_component	nonhomologous end joining complex
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071480	biological_process	cellular response to gamma radiation
A	0071481	biological_process	cellular response to X-ray
A	0097110	molecular_function	scaffold protein binding
A	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006351	biological_process	DNA-templated transcription
B	0006974	biological_process	DNA damage response
B	0007004	biological_process	telomere maintenance via telomerase
B	0008047	molecular_function	enzyme activator activity
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032040	cellular_component	small-subunit processome
B	0032204	biological_process	regulation of telomere maintenance
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034462	biological_process	small-subunit processome assembly
B	0034511	molecular_function	U3 snoRNA binding
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0042254	biological_process	ribosome biogenesis
B	0043138	molecular_function	3'-5' DNA helicase activity
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0070198	biological_process	protein localization to chromosome, telomeric region
B	0070419	cellular_component	nonhomologous end joining complex
B	0071480	biological_process	cellular response to gamma radiation
B	0090734	cellular_component	site of DNA damage
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	1904430	biological_process	negative regulation of t-circle formation
B	1990904	cellular_component	ribonucleoprotein complex
F	0000793	cellular_component	condensed chromosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006974	biological_process	DNA damage response
F	0010165	biological_process	response to X-ray
F	0016874	molecular_function	ligase activity
F	0019899	molecular_function	enzyme binding
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0032807	cellular_component	DNA ligase IV complex
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0035861	cellular_component	site of double-strand break
F	0042802	molecular_function	identical protein binding
F	0051351	biological_process	positive regulation of ligase activity
F	0070419	cellular_component	nonhomologous end joining complex
F	0070975	molecular_function	FHA domain binding
F	1990166	biological_process	protein localization to site of double-strand break
F	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
G	0000793	cellular_component	condensed chromosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0006302	biological_process	double-strand break repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0006974	biological_process	DNA damage response
G	0010165	biological_process	response to X-ray
G	0016874	molecular_function	ligase activity
G	0019899	molecular_function	enzyme binding
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0032807	cellular_component	DNA ligase IV complex
G	0033152	biological_process	immunoglobulin V(D)J recombination
G	0035861	cellular_component	site of double-strand break
G	0042802	molecular_function	identical protein binding
G	0051351	biological_process	positive regulation of ligase activity
G	0070419	cellular_component	nonhomologous end joining complex
G	0070975	molecular_function	FHA domain binding
G	1990166	biological_process	protein localization to site of double-strand break
G	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
H	0000723	biological_process	telomere maintenance
H	0001650	cellular_component	fibrillar center
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
H	0006281	biological_process	DNA repair
H	0006302	biological_process	double-strand break repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006974	biological_process	DNA damage response
H	0007417	biological_process	central nervous system development
H	0010212	biological_process	response to ionizing radiation
H	0030183	biological_process	B cell differentiation
H	0030217	biological_process	T cell differentiation
H	0032807	cellular_component	DNA ligase IV complex
H	0033152	biological_process	immunoglobulin V(D)J recombination
H	0035861	cellular_component	site of double-strand break
H	0045027	molecular_function	DNA end binding
H	0051351	biological_process	positive regulation of ligase activity
H	0070182	molecular_function	DNA polymerase binding
H	0070419	cellular_component	nonhomologous end joining complex
I	0000723	biological_process	telomere maintenance
I	0001650	cellular_component	fibrillar center
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
I	0006281	biological_process	DNA repair
I	0006302	biological_process	double-strand break repair
I	0006303	biological_process	double-strand break repair via nonhomologous end joining
I	0006974	biological_process	DNA damage response
I	0007417	biological_process	central nervous system development
I	0010212	biological_process	response to ionizing radiation
I	0030183	biological_process	B cell differentiation
I	0030217	biological_process	T cell differentiation
I	0032807	cellular_component	DNA ligase IV complex
I	0033152	biological_process	immunoglobulin V(D)J recombination
I	0035861	cellular_component	site of double-strand break
I	0045027	molecular_function	DNA end binding
I	0051351	biological_process	positive regulation of ligase activity
I	0070182	molecular_function	DNA polymerase binding
I	0070419	cellular_component	nonhomologous end joining complex
J	0000166	molecular_function	nucleotide binding
J	0000723	biological_process	telomere maintenance
J	0000725	biological_process	recombinational repair
J	0000781	cellular_component	chromosome, telomeric region
J	0000783	cellular_component	nuclear telomere cap complex
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0002218	biological_process	activation of innate immune response
J	0002376	biological_process	immune system process
J	0002684	biological_process	positive regulation of immune system process
J	0003677	molecular_function	DNA binding
J	0003678	molecular_function	DNA helicase activity
J	0003684	molecular_function	damaged DNA binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003691	molecular_function	double-stranded telomeric DNA binding
J	0003723	molecular_function	RNA binding
J	0003824	molecular_function	catalytic activity
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005667	cellular_component	transcription regulator complex
J	0005694	cellular_component	chromosome
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
J	0006281	biological_process	DNA repair
J	0006303	biological_process	double-strand break repair via nonhomologous end joining
J	0006310	biological_process	DNA recombination
J	0006351	biological_process	DNA-templated transcription
J	0006974	biological_process	DNA damage response
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0010212	biological_process	response to ionizing radiation
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0016853	molecular_function	isomerase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0030332	molecular_function	cyclin binding
J	0032991	cellular_component	protein-containing complex
J	0032993	cellular_component	protein-DNA complex
J	0034774	cellular_component	secretory granule lumen
J	0042162	molecular_function	telomeric DNA binding
J	0043138	molecular_function	3'-5' DNA helicase activity
J	0043564	cellular_component	Ku70:Ku80 complex
J	0044877	molecular_function	protein-containing complex binding
J	0045027	molecular_function	DNA end binding
J	0045087	biological_process	innate immune response
J	0045621	biological_process	positive regulation of lymphocyte differentiation
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0048660	biological_process	regulation of smooth muscle cell proliferation
J	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
J	0070419	cellular_component	nonhomologous end joining complex
J	0071475	biological_process	cellular hyperosmotic salinity response
J	0071480	biological_process	cellular response to gamma radiation
J	0071481	biological_process	cellular response to X-ray
J	0097110	molecular_function	scaffold protein binding
J	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
J	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000166	molecular_function	nucleotide binding
K	0000723	biological_process	telomere maintenance
K	0000725	biological_process	recombinational repair
K	0000781	cellular_component	chromosome, telomeric region
K	0000783	cellular_component	nuclear telomere cap complex
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0002218	biological_process	activation of innate immune response
K	0002376	biological_process	immune system process
K	0003677	molecular_function	DNA binding
K	0003678	molecular_function	DNA helicase activity
K	0003684	molecular_function	damaged DNA binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003691	molecular_function	double-stranded telomeric DNA binding
K	0003723	molecular_function	RNA binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
K	0006281	biological_process	DNA repair
K	0006302	biological_process	double-strand break repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006310	biological_process	DNA recombination
K	0006351	biological_process	DNA-templated transcription
K	0006974	biological_process	DNA damage response
K	0007004	biological_process	telomere maintenance via telomerase
K	0008047	molecular_function	enzyme activator activity
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0016829	molecular_function	lyase activity
K	0016853	molecular_function	isomerase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032040	cellular_component	small-subunit processome
K	0032204	biological_process	regulation of telomere maintenance
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0034462	biological_process	small-subunit processome assembly
K	0034511	molecular_function	U3 snoRNA binding
K	0034774	cellular_component	secretory granule lumen
K	0042162	molecular_function	telomeric DNA binding
K	0042254	biological_process	ribosome biogenesis
K	0043138	molecular_function	3'-5' DNA helicase activity
K	0043564	cellular_component	Ku70:Ku80 complex
K	0044877	molecular_function	protein-containing complex binding
K	0045027	molecular_function	DNA end binding
K	0045087	biological_process	innate immune response
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0048660	biological_process	regulation of smooth muscle cell proliferation
K	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
K	0070198	biological_process	protein localization to chromosome, telomeric region
K	0070419	cellular_component	nonhomologous end joining complex
K	0071480	biological_process	cellular response to gamma radiation
K	0090734	cellular_component	site of DNA damage
K	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K	1904430	biological_process	negative regulation of t-circle formation
K	1990904	cellular_component	ribonucleoprotein complex
O	0000793	cellular_component	condensed chromosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
O	0006281	biological_process	DNA repair
O	0006284	biological_process	base-excision repair
O	0006302	biological_process	double-strand break repair
O	0006303	biological_process	double-strand break repair via nonhomologous end joining
O	0006310	biological_process	DNA recombination
O	0006974	biological_process	DNA damage response
O	0010165	biological_process	response to X-ray
O	0016874	molecular_function	ligase activity
O	0019899	molecular_function	enzyme binding
O	0030674	molecular_function	protein-macromolecule adaptor activity
O	0032807	cellular_component	DNA ligase IV complex
O	0033152	biological_process	immunoglobulin V(D)J recombination
O	0035861	cellular_component	site of double-strand break
O	0042802	molecular_function	identical protein binding
O	0051351	biological_process	positive regulation of ligase activity
O	0070419	cellular_component	nonhomologous end joining complex
O	0070975	molecular_function	FHA domain binding
O	1990166	biological_process	protein localization to site of double-strand break
O	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
P	0000793	cellular_component	condensed chromosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
P	0006281	biological_process	DNA repair
P	0006284	biological_process	base-excision repair
P	0006302	biological_process	double-strand break repair
P	0006303	biological_process	double-strand break repair via nonhomologous end joining
P	0006310	biological_process	DNA recombination
P	0006974	biological_process	DNA damage response
P	0010165	biological_process	response to X-ray
P	0016874	molecular_function	ligase activity
P	0019899	molecular_function	enzyme binding
P	0030674	molecular_function	protein-macromolecule adaptor activity
P	0032807	cellular_component	DNA ligase IV complex
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0035861	cellular_component	site of double-strand break
P	0042802	molecular_function	identical protein binding
P	0051351	biological_process	positive regulation of ligase activity
P	0070419	cellular_component	nonhomologous end joining complex
P	0070975	molecular_function	FHA domain binding
P	1990166	biological_process	protein localization to site of double-strand break
P	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
X	0000012	biological_process	single strand break repair
X	0000166	molecular_function	nucleotide binding
X	0000287	molecular_function	magnesium ion binding
X	0000781	cellular_component	chromosome, telomeric region
X	0000793	cellular_component	condensed chromosome
X	0001701	biological_process	in utero embryonic development
X	0002328	biological_process	pro-B cell differentiation
X	0003677	molecular_function	DNA binding
X	0003909	molecular_function	DNA ligase activity
X	0003910	molecular_function	DNA ligase (ATP) activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
X	0006281	biological_process	DNA repair
X	0006284	biological_process	base-excision repair
X	0006297	biological_process	nucleotide-excision repair, DNA gap filling
X	0006302	biological_process	double-strand break repair
X	0006303	biological_process	double-strand break repair via nonhomologous end joining
X	0006310	biological_process	DNA recombination
X	0006974	biological_process	DNA damage response
X	0007417	biological_process	central nervous system development
X	0008283	biological_process	cell population proliferation
X	0010165	biological_process	response to X-ray
X	0010212	biological_process	response to ionizing radiation
X	0010332	biological_process	response to gamma radiation
X	0016874	molecular_function	ligase activity
X	0032807	cellular_component	DNA ligase IV complex
X	0033077	biological_process	T cell differentiation in thymus
X	0033151	biological_process	V(D)J recombination
X	0033152	biological_process	immunoglobulin V(D)J recombination
X	0033153	biological_process	T cell receptor V(D)J recombination
X	0035019	biological_process	somatic stem cell population maintenance
X	0043524	biological_process	negative regulation of neuron apoptotic process
X	0045190	biological_process	isotype switching
X	0046872	molecular_function	metal ion binding
X	0048146	biological_process	positive regulation of fibroblast proliferation
X	0050769	biological_process	positive regulation of neurogenesis
X	0051276	biological_process	chromosome organization
X	0051301	biological_process	cell division
X	0051402	biological_process	neuron apoptotic process
X	0070419	cellular_component	nonhomologous end joining complex
X	0071479	biological_process	cellular response to ionizing radiation
X	0071897	biological_process	DNA biosynthetic process
X	0075713	biological_process	establishment of integrated proviral latency
X	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
X	2001252	biological_process	positive regulation of chromosome organization
Y	0000012	biological_process	single strand break repair
Y	0000166	molecular_function	nucleotide binding
Y	0000287	molecular_function	magnesium ion binding
Y	0000781	cellular_component	chromosome, telomeric region
Y	0000793	cellular_component	condensed chromosome
Y	0001701	biological_process	in utero embryonic development
Y	0002328	biological_process	pro-B cell differentiation
Y	0003677	molecular_function	DNA binding
Y	0003909	molecular_function	DNA ligase activity
Y	0003910	molecular_function	DNA ligase (ATP) activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Y	0006281	biological_process	DNA repair
Y	0006284	biological_process	base-excision repair
Y	0006297	biological_process	nucleotide-excision repair, DNA gap filling
Y	0006302	biological_process	double-strand break repair
Y	0006303	biological_process	double-strand break repair via nonhomologous end joining
Y	0006310	biological_process	DNA recombination
Y	0006974	biological_process	DNA damage response
Y	0007417	biological_process	central nervous system development
Y	0008283	biological_process	cell population proliferation
Y	0010165	biological_process	response to X-ray
Y	0010212	biological_process	response to ionizing radiation
Y	0010332	biological_process	response to gamma radiation
Y	0016874	molecular_function	ligase activity
Y	0032807	cellular_component	DNA ligase IV complex
Y	0033077	biological_process	T cell differentiation in thymus
Y	0033151	biological_process	V(D)J recombination
Y	0033152	biological_process	immunoglobulin V(D)J recombination
Y	0033153	biological_process	T cell receptor V(D)J recombination
Y	0035019	biological_process	somatic stem cell population maintenance
Y	0043524	biological_process	negative regulation of neuron apoptotic process
Y	0045190	biological_process	isotype switching
Y	0046872	molecular_function	metal ion binding
Y	0048146	biological_process	positive regulation of fibroblast proliferation
Y	0050769	biological_process	positive regulation of neurogenesis
Y	0051276	biological_process	chromosome organization
Y	0051301	biological_process	cell division
Y	0051402	biological_process	neuron apoptotic process
Y	0070419	cellular_component	nonhomologous end joining complex
Y	0071479	biological_process	cellular response to ionizing radiation
Y	0071897	biological_process	DNA biosynthetic process
Y	0075713	biological_process	establishment of integrated proviral latency
Y	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
Y	2001252	biological_process	positive regulation of chromosome organization

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
X	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
X	GLU271-MET279

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	414
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	218
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	398
Details	Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	54
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	136
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	84
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"18046455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Leu-lock","evidences":[{"source":"PubMed","id":"21775435","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"18644470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	206
Details	Domain: {"description":"BRCT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29980672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P18858","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---