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7LS5

Cryo-EM structure of the Pre3-1 20S proteasome core particle

Functional Information from GO Data
ChainGOidnamespacecontents
10000502cellular_componentproteasome complex
10003674molecular_functionmolecular_function
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005737cellular_componentcytoplasm
10005829cellular_componentcytosol
10005839cellular_componentproteasome core complex
10010499biological_processproteasomal ubiquitin-independent protein catabolic process
10019774cellular_componentproteasome core complex, beta-subunit complex
10043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
10051603biological_processproteolysis involved in protein catabolic process
20000502cellular_componentproteasome complex
20003674molecular_functionmolecular_function
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005737cellular_componentcytoplasm
20005829cellular_componentcytosol
20005839cellular_componentproteasome core complex
20010499biological_processproteasomal ubiquitin-independent protein catabolic process
20019774cellular_componentproteasome core complex, beta-subunit complex
20034515cellular_componentproteasome storage granule
20043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
20043248biological_processproteasome assembly
20051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010499biological_processproteasomal ubiquitin-independent protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034515cellular_componentproteasome storage granule
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0034515cellular_componentproteasome storage granule
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0080129biological_processproteasome core complex assembly
D0000502cellular_componentproteasome complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034515cellular_componentproteasome storage granule
D0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010499biological_processproteasomal ubiquitin-independent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034515cellular_componentproteasome storage granule
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010499biological_processproteasomal ubiquitin-independent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0034515cellular_componentproteasome storage granule
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0003729molecular_functionmRNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0010499biological_processproteasomal ubiquitin-independent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0034515cellular_componentproteasome storage granule
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005839cellular_componentproteasome core complex
H0006508biological_processproteolysis
H0010499biological_processproteasomal ubiquitin-independent protein catabolic process
H0019774cellular_componentproteasome core complex, beta-subunit complex
H0034515cellular_componentproteasome storage granule
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005839cellular_componentproteasome core complex
I0006508biological_processproteolysis
I0010499biological_processproteasomal ubiquitin-independent protein catabolic process
I0019774cellular_componentproteasome core complex, beta-subunit complex
I0034515cellular_componentproteasome storage granule
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0010499biological_processproteasomal ubiquitin-independent protein catabolic process
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0061133molecular_functionendopeptidase activator activity
K0000502cellular_componentproteasome complex
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005789cellular_componentendoplasmic reticulum membrane
K0005829cellular_componentcytosol
K0005839cellular_componentproteasome core complex
K0010498biological_processproteasomal protein catabolic process
K0010499biological_processproteasomal ubiquitin-independent protein catabolic process
K0019774cellular_componentproteasome core complex, beta-subunit complex
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
K0061133molecular_functionendopeptidase activator activity
L0000502cellular_componentproteasome complex
L0004175molecular_functionendopeptidase activity
L0004298molecular_functionthreonine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005777cellular_componentperoxisome
L0005829cellular_componentcytosol
L0005839cellular_componentproteasome core complex
L0006508biological_processproteolysis
L0010499biological_processproteasomal ubiquitin-independent protein catabolic process
L0019774cellular_componentproteasome core complex, beta-subunit complex
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
L0080129biological_processproteasome core complex assembly
M0000502cellular_componentproteasome complex
M0003674molecular_functionmolecular_function
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005839cellular_componentproteasome core complex
M0010499biological_processproteasomal ubiquitin-independent protein catabolic process
M0019774cellular_componentproteasome core complex, beta-subunit complex
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0051603biological_processproteolysis involved in protein catabolic process
N0000502cellular_componentproteasome complex
N0003674molecular_functionmolecular_function
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005839cellular_componentproteasome core complex
N0010499biological_processproteasomal ubiquitin-independent protein catabolic process
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0034515cellular_componentproteasome storage granule
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0043248biological_processproteasome assembly
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0003674molecular_functionmolecular_function
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005739cellular_componentmitochondrion
O0005839cellular_componentproteasome core complex
O0006511biological_processubiquitin-dependent protein catabolic process
O0010499biological_processproteasomal ubiquitin-independent protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
P0000502cellular_componentproteasome complex
P0003674molecular_functionmolecular_function
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005839cellular_componentproteasome core complex
P0006511biological_processubiquitin-dependent protein catabolic process
P0010499biological_processproteasomal ubiquitin-independent protein catabolic process
P0019773cellular_componentproteasome core complex, alpha-subunit complex
P0034515cellular_componentproteasome storage granule
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0051603biological_processproteolysis involved in protein catabolic process
Q0000502cellular_componentproteasome complex
Q0003674molecular_functionmolecular_function
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005839cellular_componentproteasome core complex
Q0006511biological_processubiquitin-dependent protein catabolic process
Q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0034515cellular_componentproteasome storage granule
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
Q0080129biological_processproteasome core complex assembly
R0000502cellular_componentproteasome complex
R0003674molecular_functionmolecular_function
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0005739cellular_componentmitochondrion
R0005839cellular_componentproteasome core complex
R0006511biological_processubiquitin-dependent protein catabolic process
R0010499biological_processproteasomal ubiquitin-independent protein catabolic process
R0019773cellular_componentproteasome core complex, alpha-subunit complex
R0034515cellular_componentproteasome storage granule
R0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
S0000502cellular_componentproteasome complex
S0003674molecular_functionmolecular_function
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005737cellular_componentcytoplasm
S0005839cellular_componentproteasome core complex
S0006511biological_processubiquitin-dependent protein catabolic process
S0010499biological_processproteasomal ubiquitin-independent protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0034515cellular_componentproteasome storage granule
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
T0000502cellular_componentproteasome complex
T0003674molecular_functionmolecular_function
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005737cellular_componentcytoplasm
T0005839cellular_componentproteasome core complex
T0006511biological_processubiquitin-dependent protein catabolic process
T0010499biological_processproteasomal ubiquitin-independent protein catabolic process
T0019773cellular_componentproteasome core complex, alpha-subunit complex
T0034515cellular_componentproteasome storage granule
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0051603biological_processproteolysis involved in protein catabolic process
U0000502cellular_componentproteasome complex
U0003729molecular_functionmRNA binding
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005737cellular_componentcytoplasm
U0005839cellular_componentproteasome core complex
U0006511biological_processubiquitin-dependent protein catabolic process
U0010499biological_processproteasomal ubiquitin-independent protein catabolic process
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0034515cellular_componentproteasome storage granule
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0051603biological_processproteolysis involved in protein catabolic process
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005634cellular_componentnucleus
V0005737cellular_componentcytoplasm
V0005829cellular_componentcytosol
V0005839cellular_componentproteasome core complex
V0006508biological_processproteolysis
V0010499biological_processproteasomal ubiquitin-independent protein catabolic process
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0034515cellular_componentproteasome storage granule
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0051603biological_processproteolysis involved in protein catabolic process
W0000502cellular_componentproteasome complex
W0004175molecular_functionendopeptidase activity
W0004298molecular_functionthreonine-type endopeptidase activity
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0005839cellular_componentproteasome core complex
W0006508biological_processproteolysis
W0010499biological_processproteasomal ubiquitin-independent protein catabolic process
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0034515cellular_componentproteasome storage granule
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
X0000502cellular_componentproteasome complex
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005839cellular_componentproteasome core complex
X0010499biological_processproteasomal ubiquitin-independent protein catabolic process
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
X0061133molecular_functionendopeptidase activator activity
Y0000502cellular_componentproteasome complex
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005737cellular_componentcytoplasm
Y0005789cellular_componentendoplasmic reticulum membrane
Y0005829cellular_componentcytosol
Y0005839cellular_componentproteasome core complex
Y0010498biological_processproteasomal protein catabolic process
Y0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Y0019774cellular_componentproteasome core complex, beta-subunit complex
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0051603biological_processproteolysis involved in protein catabolic process
Y0061133molecular_functionendopeptidase activator activity
Z0000502cellular_componentproteasome complex
Z0004175molecular_functionendopeptidase activity
Z0004298molecular_functionthreonine-type endopeptidase activity
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005777cellular_componentperoxisome
Z0005829cellular_componentcytosol
Z0005839cellular_componentproteasome core complex
Z0006508biological_processproteolysis
Z0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0051603biological_processproteolysis involved in protein catabolic process
Z0080129biological_processproteasome core complex assembly
Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrhiTiFSPeGRlyQVEYAfkA
ChainResidueDetails
ATYR12-ALA34
GTYR7-ALA29
CTYR6-SER28
ETYR8-ALA30
DTYR4-ALA26
BTYR5-ALA27
FTYR6-ALA28

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD
ChainResidueDetails
IVAL4-ASP51
JVAL12-ASP58
1LEU13-ASP60
2ILE12-ASP59
CILE36-ASP83
LLEU80-ASP127
DVAL34-ASP81
KLEU4-ASP51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:9087403
ChainResidueDetails
ITHR1
WTHR1
CLYS199
CLYS231
QLYS100
QLYS199
QLYS231

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
HMET-18
VMET-18
TLYS191

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ESER251
SSER251
OLYS232

Catalytic Information from CSA
site_idMCSA1
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
ITHR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
IASP17activator, steric locator
IARG19activator
ILYS33activator, electrostatic stabiliser
IGLY47electrostatic stabiliser
ISER129activator, electrostatic stabiliser
IASP166activator, steric locator
ISER169activator, electrostatic stabiliser

site_idMCSA2
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
WTHR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
WASP17activator, steric locator
WARG19activator
WLYS33activator, electrostatic stabiliser
WGLY47electrostatic stabiliser
WSER129activator, electrostatic stabiliser
WASP166activator, steric locator
WSER169activator, electrostatic stabiliser

227344

PDB entries from 2024-11-13

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