Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7LQN

Glucosamine-6-phosphate Deaminase from H. influenzae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006043	biological_process	glucosamine catabolic process
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006046	biological_process	N-acetylglucosamine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0042802	molecular_function	identical protein binding
B	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006043	biological_process	glucosamine catabolic process
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006046	biological_process	N-acetylglucosamine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0042802	molecular_function	identical protein binding
C	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006043	biological_process	glucosamine catabolic process
C	0006044	biological_process	N-acetylglucosamine metabolic process
C	0006046	biological_process	N-acetylglucosamine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0042802	molecular_function	identical protein binding
D	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006043	biological_process	glucosamine catabolic process
D	0006044	biological_process	N-acetylglucosamine metabolic process
D	0006046	biological_process	N-acetylglucosamine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0042802	molecular_function	identical protein binding
E	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0006043	biological_process	glucosamine catabolic process
E	0006044	biological_process	N-acetylglucosamine metabolic process
E	0006046	biological_process	N-acetylglucosamine catabolic process
E	0016787	molecular_function	hydrolase activity
E	0019262	biological_process	N-acetylneuraminate catabolic process
E	0042802	molecular_function	identical protein binding
F	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0006043	biological_process	glucosamine catabolic process
F	0006044	biological_process	N-acetylglucosamine metabolic process
F	0006046	biological_process	N-acetylglucosamine catabolic process
F	0016787	molecular_function	hydrolase activity
F	0019262	biological_process	N-acetylneuraminate catabolic process
F	0042802	molecular_function	identical protein binding
G	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0006043	biological_process	glucosamine catabolic process
G	0006044	biological_process	N-acetylglucosamine metabolic process
G	0006046	biological_process	N-acetylglucosamine catabolic process
G	0016787	molecular_function	hydrolase activity
G	0019262	biological_process	N-acetylneuraminate catabolic process
G	0042802	molecular_function	identical protein binding
H	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0006043	biological_process	glucosamine catabolic process
H	0006044	biological_process	N-acetylglucosamine metabolic process
H	0006046	biological_process	N-acetylglucosamine catabolic process
H	0016787	molecular_function	hydrolase activity
H	0019262	biological_process	N-acetylneuraminate catabolic process
H	0042802	molecular_function	identical protein binding
I	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005975	biological_process	carbohydrate metabolic process
I	0006043	biological_process	glucosamine catabolic process
I	0006044	biological_process	N-acetylglucosamine metabolic process
I	0006046	biological_process	N-acetylglucosamine catabolic process
I	0016787	molecular_function	hydrolase activity
I	0019262	biological_process	N-acetylneuraminate catabolic process
I	0042802	molecular_function	identical protein binding
J	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005975	biological_process	carbohydrate metabolic process
J	0006043	biological_process	glucosamine catabolic process
J	0006044	biological_process	N-acetylglucosamine metabolic process
J	0006046	biological_process	N-acetylglucosamine catabolic process
J	0016787	molecular_function	hydrolase activity
J	0019262	biological_process	N-acetylneuraminate catabolic process
J	0042802	molecular_function	identical protein binding
K	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005975	biological_process	carbohydrate metabolic process
K	0006043	biological_process	glucosamine catabolic process
K	0006044	biological_process	N-acetylglucosamine metabolic process
K	0006046	biological_process	N-acetylglucosamine catabolic process
K	0016787	molecular_function	hydrolase activity
K	0019262	biological_process	N-acetylneuraminate catabolic process
K	0042802	molecular_function	identical protein binding
L	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005975	biological_process	carbohydrate metabolic process
L	0006043	biological_process	glucosamine catabolic process
L	0006044	biological_process	N-acetylglucosamine metabolic process
L	0006046	biological_process	N-acetylglucosamine catabolic process
L	0016787	molecular_function	hydrolase activity
L	0019262	biological_process	N-acetylneuraminate catabolic process
L	0042802	molecular_function	identical protein binding

Functional Information from PROSITE/UniProt

site_id	PS01161
Number of Residues	19
Details	GLC_GALNAC_ISOMERASE Glucosamine/galactosamine-6-phosphate isomerases signature. IksyGkIhLfMgGVGvDGH

Chain	Residue	Details
A	ILE125-HIS143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor; for enolization step => ECO:0000255\|HAMAP-Rule:MF_01241

Chain	Residue	Details
B	ASP72
C	ASP72
D	ASP72
E	ASP72
F	ASP72
G	ASP72
H	ASP72
I	ASP72
J	ASP72
K	ASP72
L	ASP72
A	ASP72

site_id	SWS_FT_FI2
Number of Residues	24
Details	ACT_SITE: For ring-opening step => ECO:0000255\|HAMAP-Rule:MF_01241

Chain	Residue	Details
B	ASP141
B	GLU148
C	ASP141
C	GLU148
D	ASP141
D	GLU148
E	ASP141
E	GLU148
F	ASP141
F	GLU148
G	ASP141
G	GLU148
H	ASP141
H	GLU148
I	ASP141
I	GLU148
J	ASP141
J	GLU148
K	ASP141
K	GLU148
L	ASP141
L	GLU148
A	ASP141
A	GLU148

site_id	SWS_FT_FI3
Number of Residues	12
Details	ACT_SITE: Proton acceptor; for ring-opening step => ECO:0000255\|HAMAP-Rule:MF_01241

Chain	Residue	Details
B	HIS143
C	HIS143
D	HIS143
E	HIS143
F	HIS143
G	HIS143
H	HIS143
I	HIS143
J	HIS143
K	HIS143
L	HIS143
A	HIS143

site_id	SWS_FT_FI4
Number of Residues	60
Details	SITE: Part of the allosteric site => ECO:0000255\|HAMAP-Rule:MF_01241

Chain	Residue	Details
B	SER151
B	ARG158
B	LYS160
B	THR161
B	TYR254
C	SER151
C	ARG158
C	LYS160
C	THR161
C	TYR254
D	SER151
D	ARG158
D	LYS160
D	THR161
D	TYR254
E	SER151
E	ARG158
E	LYS160
E	THR161
E	TYR254
F	SER151
F	ARG158
F	LYS160
F	THR161
F	TYR254
G	SER151
G	ARG158
G	LYS160
G	THR161
G	TYR254
H	SER151
H	ARG158
H	LYS160
H	THR161
H	TYR254
I	SER151
I	ARG158
I	LYS160
I	THR161
I	TYR254
J	SER151
J	ARG158
J	LYS160
J	THR161
J	TYR254
K	SER151
K	ARG158
K	LYS160
K	THR161
K	TYR254
L	SER151
L	ARG158
L	LYS160
L	THR161
L	TYR254
A	SER151
A	ARG158
A	LYS160
A	THR161
A	TYR254

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)