7LJB
Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| D | TYR191-HIS197 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Intramembrane: {"description":"Pore-forming; Name=PH1","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=M3","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Intramembrane: {"description":"Pore-forming; Name=PH2","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=M4","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
