7LHS

Crystal structure of adenosine-5'-phosphosulfate reductase from Mycobacterium tuberculosis in a complex with substrate APS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0016491	molecular_function	oxidoreductase activity
A	0019344	biological_process	cysteine biosynthetic process
A	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
A	0043866	molecular_function	adenylyl-sulfate reductase (thioredoxin) activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0070814	biological_process	hydrogen sulfide biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0016491	molecular_function	oxidoreductase activity
B	0019344	biological_process	cysteine biosynthetic process
B	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
B	0043866	molecular_function	adenylyl-sulfate reductase (thioredoxin) activity
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0070814	biological_process	hydrogen sulfide biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile; cysteine thiosulfonate intermediate => ECO:0000255|HAMAP-Rule:MF_00063

Chain	Residue	Details
A	CYS249
B	CYS249

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00063, ECO:0000269|PubMed:34095667, ECO:0007744|PDB:7LHR, ECO:0007744|PDB:7LHS, ECO:0007744|PDB:7LHU

Chain	Residue	Details
A	CYS140
A	CYS141
A	CYS223
A	CYS226
B	CYS140
B	CYS141
B	CYS223
B	CYS226

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:34095667, ECO:0007744|PDB:7LHU

Chain	Residue	Details
A	ALA64
A	LEU88
A	GLY162
B	ALA64
B	LEU88
B	GLY162

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:34095667, ECO:0007744|PDB:7LHS

Chain	Residue	Details
A	ASP167
B	ASP167

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